[HTML][HTML] COVID-19 and tuberculosis: the double whammy of respiratory pathogens

M Shariq, JA Sheikh, N Quadir… - European …, 2022 - Eur Respiratory Soc
Prior to coronavirus disease 2019 (COVID-19), tuberculosis (TB) was the worst killer among
infectious diseases. The union of these two obnoxious respiratory diseases can be …

[HTML][HTML] Inflammation-mediated tissue damage in pulmonary tuberculosis and host-directed therapeutic strategies

D Tiwari, AR Martineau - Seminars in Immunology, 2023 - Elsevier
Abstract Treatment of tuberculosis (TB) involves the administration of anti-mycobacterial
drugs for several months. The emergence of drug-resistant strains of Mycobacterium …

Treatment strategy for rifampin-susceptible tuberculosis

NI Paton, C Cousins, C Suresh, E Burhan… - … England Journal of …, 2023 - Mass Medical Soc
Background Tuberculosis is usually treated with a 6-month rifampin-based regimen.
Whether a strategy involving shorter initial treatment may lead to similar outcomes is …

Artificial intelligence techniques to predict the airway disorders illness: a systematic review

A Koul, RK Bawa, Y Kumar - Archives of Computational Methods in …, 2023 - Springer
Airway disease is a major healthcare issue that causes at least 3 million fatalities every year.
It is also considered one of the foremost causes of death all around the globe by 2030 …

Ending tuberculosis in China: health system challenges

Q Long, L Guo, W Jiang, S Huan, S Tang - The Lancet Public Health, 2021 - thelancet.com
China has made remarkable progress in reducing tuberculosis cases and deaths during the
past three decades; however, it is still far from achieving the targets set out in the WHO End …

Immunological factors linked to geographical variation in vaccine responses

MMAR van Dorst, JJ Pyuza, G Nkurunungi… - Nature Reviews …, 2024 - nature.com
Vaccination is one of medicine's greatest achievements; however, its full potential is
hampered by considerable variation in efficacy across populations and geographical …

The promising potential of reverse vaccinology-based next-generation vaccine development over conventional vaccines against antibiotic-resistant bacteria

K Khalid, CL Poh - Vaccines, 2023 - mdpi.com
The clinical use of antibiotics has led to the emergence of multidrug-resistant (MDR)
bacteria, leading to the current antibiotic resistance crisis. To address this issue, next …

Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis

Y Imai, G Hauk, J Quigley, L Liang, S Son… - Nature chemical …, 2022 - nature.com
The antimicrobial resistance crisis requires the introduction of novel antibiotics. The use of
conventional broad-spectrum compounds selects for resistance in off-target pathogens and …

DprE2 is a molecular target of the anti-tubercular nitroimidazole compounds pretomanid and delamanid

KA Abrahams, SM Batt, SS Gurcha, N Veerapen… - Nature …, 2023 - nature.com
Mycobacterium tuberculosis is one of the global leading causes of death due to a single
infectious agent. Pretomanid and delamanid are new antitubercular agents that have …

A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages

M Bedard, S van der Niet, EM Bernard… - The Journal of …, 2023 - Am Soc Clin Investig
Induction of lipid-laden foamy macrophages is a cellular hallmark of tuberculosis (TB)
disease, which involves the transformation of infected phagolysosomes from a site of killing …