Risk of severe and fatal ventricular arrhythmias, presenting as Torsade de Pointes (TdP), is
increased in congenital and acquired forms of long QT syndromes (LQTS). Drug-induced …

Introduction: Centipedes are one of the oldest and most successful lineages of venomous
terrestrial predators. Despite their use for centuries in traditional medicine, centipede …

Calcium-activated chloride channels (CaCCs) play vital roles in a variety of physiological
processes. Dysfunction of the CaCCs is implicated in many diseases. Drug discovery …

Puerarin, a known isoflavone, is commonly found as a Chinese herb medicine. It is widely
used in China to treat cardiac diseases such as angina, cardiac infarction and arrhythmia …

Scorpine is an antimicrobial and antimalarial peptide isolated from Pandinus imperator
scorpion venom. As there are few functional and structural studies reported on scorpine-like …

The Kv1. 3 channel plays potential roles in immune, inflammation and coagulation system.
Many studies showed that Kv1. 3 channel inhibitors have immunosuppressive and anti …

The human defensins are recently discovered to inhibit potassium channels, which are
classical targets of the animal toxins. Whether other vertebrate defensins are potassium …

Schistosoma japonicum is a parasitic worm that lives in the mesenteric vein of its host and
feeds on blood, suggesting that it might be a natural resource of novel anticoagulants. Here …

Insect selective excitatory β-type sodium channel neurotoxins from scorpion venom (β-
NaScTxs) are composed of about 70–76 amino acid residues and share a common scaffold …