[HTML][HTML] Smart/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications

HM El-Husseiny, EA Mady, L Hamabe, A Abugomaa… - Materials Today Bio, 2022 - Elsevier
Recently, biomedicine and tissue regeneration have emerged as great advances that
impacted the spectrum of healthcare. This left the door open for further improvement of their …

Recent progress in aptamer discoveries and modifications for therapeutic applications

S Ni, Z Zhuo, Y Pan, Y Yu, F Li, J Liu… - … Applied Materials & …, 2020 - ACS Publications
Aptamers are oligonucleotide sequences with a length of about 25–80 bases which have
abilities to bind to specific target molecules that rival those of monoclonal antibodies. They …

Acid-resistant and physiological pH-responsive DNA hydrogel composed of A-motif and i-motif toward oral insulin delivery

Y Hu, S Gao, H Lu, JY Ying - Journal of the American Chemical …, 2022 - ACS Publications
An acid-resistant DNA hydrogel that is stable in an extremely acidic environment with pH as
low as 1.2 has not been reported before, largely due to the instability of DNA-hybridized …

DNA hydrogel-based gene editing and drug delivery systems

F Mo, K Jiang, D Zhao, Y Wang, J Song… - Advanced Drug Delivery …, 2021 - Elsevier
Deoxyribonucleic acid (DNA) is a promising synthesizer for precisely constructing almost
arbitrary geometry in two and three dimensions. Among various DNA-based soft materials …

Programmable CRISPR-responsive smart materials

MA English, LR Soenksen, RV Gayet, H de Puig… - Science, 2019 - science.org
Stimuli-responsive materials activated by biological signals play an increasingly important
role in biotechnology applications. We exploit the programmability of CRISPR-associated …

Detection and beyond: Challenges and advances in aptamer-based biosensors

H Yoo, H Jo, SS Oh - Materials Advances, 2020 - pubs.rsc.org
Beyond traditional needs of biosensors such as high sensitivity and selectivity for analyte
detection, newly emerging requirements including a real-time detection ability and in-field …

DNA hydrogels and microgels for biosensing and biomedical applications

F Li, D Lyu, S Liu, W Guo - Advanced Materials, 2020 - Wiley Online Library
DNA hydrogels, which take advantage of the unique properties of functional DNA motifs,
such as specific molecular recognition, programmable and high‐precision assembly …

Smart/stimuli-responsive hydrogels: State-of-the-art platforms for bone tissue engineering

HM El-Husseiny, EA Mady, WA El-Dakroury… - Applied Materials …, 2022 - Elsevier
Repair of bone defects is a time-consuming, self-healing process based on tissue modeling
and remodeling. However, the capacity of this method is limited, especially for critical-sized …

Thermal‐responsive MXene‐DNA hydrogel for near‐infrared light triggered localized photothermal‐chemo synergistic cancer therapy

PP He, X Du, Y Cheng, Q Gao, C Liu, X Wang, Y Wei… - Small, 2022 - Wiley Online Library
Stimuli‐responsive DNA hydrogels are promising candidates for cancer treatment, as they
not only possess biocompatible and biodegradable 3D network structures as highly efficient …

Biomedical applications of DNA‐based hydrogels

J Gačanin, CV Synatschke… - Advanced Functional …, 2020 - Wiley Online Library
Nucleic acids are gaining significant attention as versatile building blocks for the next
generation of soft materials. Due to significant advances in the chemical synthesis and …