The aetiology and molecular landscape of insulin resistance
Insulin resistance, defined as a defect in insulin-mediated control of glucose metabolism in
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …
Pathophysiology of type 2 diabetes mellitus
U Galicia-Garcia, A Benito-Vicente, S Jebari… - International journal of …, 2020 - mdpi.com
Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused
by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and …
by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and …
The trans-ancestral genomic architecture of glycemic traits
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic
health. To date, most genetic studies of glycemic traits have focused on individuals of …
health. To date, most genetic studies of glycemic traits have focused on individuals of …
Cardiovascular risk factors and physical activity for the prevention of cardiovascular diseases in the elderly
Cardiovascular diseases create an important burden on the public health systems,
especially in the elderly, mostly because this group of patients frequently suffer from multiple …
especially in the elderly, mostly because this group of patients frequently suffer from multiple …
Chronic tissue inflammation and metabolic disease
YS Lee, J Olefsky - Genes & development, 2021 - genesdev.cshlp.org
Obesity is the most common cause of insulin resistance, and the current obesity epidemic is
driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic …
driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic …
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130
European-descent individuals (9% cases), after imputation to high-density reference panels …
European-descent individuals (9% cases), after imputation to high-density reference panels …
Global aetiology and epidemiology of type 2 diabetes mellitus and its complications
Globally, the number of people with diabetes mellitus has quadrupled in the past three
decades, and diabetes mellitus is the ninth major cause of death. About 1 in 11 adults …
decades, and diabetes mellitus is the ninth major cause of death. About 1 in 11 adults …
Periodontitis and implant complications in diabetes
L Nibali, N Gkranias, G Mainas… - Periodontology 2000, 2022 - Wiley Online Library
Epidemiologic evidence indicates that periodontitis is more frequent in patients with
uncontrolled diabetes mellitus than in healthy controls, suggesting that it could be …
uncontrolled diabetes mellitus than in healthy controls, suggesting that it could be …
Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: a soft clustering analysis
Background Type 2 diabetes (T2D) is a heterogeneous disease for which (1) disease-
causing pathways are incompletely understood and (2) subclassification may improve …
causing pathways are incompletely understood and (2) subclassification may improve …
Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms
Being a morning person is a behavioural indicator of a person's underlying circadian rhythm.
Using genome-wide data from 697,828 UK Biobank and 23andMe participants we increase …
Using genome-wide data from 697,828 UK Biobank and 23andMe participants we increase …