Metabolic syndrome and obesity have become important health issues of epidemic
proportions and are often the cause of related pathologies such as type 2 diabetes (T2DM) …

One of the most common complications during pregnancy is gestational diabetes mellitus
(GDM), hyperglycemia that occurs for the first time during pregnancy. The condition is …

Background: Adverse environmental exposure during the prenatal period can lead to
diseases in the offspring, including hypertension. Whether or not the hypertensive …

While human adaptability is regarded as a classical topic in anthropology, recent work
provides new insight into metabolic adaptations to cold climates and the role of phenotypic …

Obesity is a critical risk factor causing the development of metabolic diseases and cancers.
Its increasing prevalence worldwide has aroused great concerns of the researchers on …

Post-translational and epigenetic regulation are important mechanisms controlling functions
of genes and proteins. Although the “classic” estrogen receptors (ERs) have been …

The importance of defining cell-type-specific genes is well acknowledged. Technological
advances facilitate high-resolution sequencing of single cells, but practical challenges …

The rising prevalence of obesity over the past decades coincides with the rising awareness
that a detailed understanding of both adipose tissue biology and obesity‐associated …

Background In contrast with genetics, epigenetics does not alter the DNA sequence. It was a
widely held thought that although the epigenome undergoes a process of reprogramming …

Background Expression quantitative trait loci (eQTL) studies provide insights into regulatory
mechanisms underlying disease risk. Expanding studies of gene regulation to …