Interactions between DNA and Gemini surfactant: impact on gene therapy: part I

T Ahmed, AO Kamel, SD Wettig - Nanomedicine, 2016 - Taylor & Francis
Nonviral gene therapy using gemini surfactants is a unique approach to medicine that can
be adapted toward the treatment of various diseases. Recently, gemini surfactants have …

Inhaled gene delivery: a formulation and delivery approach

L Gomes dos Reis, M Svolos, B Hartwig… - Expert Opinion on …, 2017 - Taylor & Francis
Introduction: Gene therapy is a potential alternative to treat a number of diseases. Different
hurdles are associated with aerosol gene delivery due to the susceptibility of plasmid DNA …

[PDF][PDF] Surfactants: pharmaceutical and medicinal aspects

BS Sekhon - Journal of Pharmaceutical Technology, Research …, 2013 - jptrm.chitkara.edu.in
Surfactants are amphipathic substances with lyophobic and lyophilic groups and are critical
components in pharmaceutical products. Surfactants have several uses in pharmaceuticals …

Bis-quaternary gemini surfactants as components of nonviral gene delivery systems: A comprehensive study from physicochemical properties to membrane …

AM Cardoso, CM Morais, SG Silva, EF Marques… - International Journal of …, 2014 - Elsevier
Gemini surfactants have been successfully used as components of gene delivery systems. In
the present work, a family of gemini surfactants, represented by the general structure [C m H …

Cellular uptake and distribution of gemini surfactant nanoparticles used as gene delivery agents

W Jin, M Al-Dulaymi, I Badea, SC Leary, J Rehman… - The AAPS journal, 2019 - Springer
Gemini surfactants are promising molecules utilized as non-viral gene delivery vectors.
However, little is known about their cellular uptake and distribution after they release their …

Maltotriose acylhydrazone surfactants: Structure-property profiles and efficient in vivo drug delivery for primary biliary cholangitis treatment

Y Liu, X Xiang, B Wang, F Lu, Y Dai, Z Zhang… - Journal of Molecular …, 2023 - Elsevier
Bio-based surfactants derived from carbohydrates have attracted increasing attention due to
their environmental friendliness, biodegradability, and biological functions. In this study, we …

Effects of cationic lipids in cationic liposomes and disaccharides in the freeze-drying of siRNA lipoplexes on gene silencing in cells by reverse transfection

Y Hattori, S Hu, H Onishi - Journal of Liposome Research, 2020 - Taylor & Francis
RNA interference is a promising technology to inhibit the production of target proteins, and
screening with synthetic small interfering RNA (siRNA) libraries has become a crucial …

Application of lyophilized gene-delivery formulations to dental implant surfaces: non-cariogenic lyoprotectant preserves transfection activity of polyplexes long-term

WI Malkawi, NZ Laird, P Phruttiwanichakun… - Journal of …, 2023 - Elsevier
Titanium is the metal of choice for dental implants because of its biocompatibility and ability
to merge with human bone tissue. Despite the great success rate of dental implants, early …

Physical characterization of gemini surfactant-based synthetic vectors for the delivery of linear covalently closed (LCC) DNA ministrings

CH Sum, N Nafissi, RA Slavcev, S Wettig - PLoS One, 2015 - journals.plos.org
In combination with novel l inear c ovalently c losed (LCC) DNA minivectors, referred to as
DNA ministrings, a gemini surfactant-based synthetic vector for gene delivery has been …

A 89Zr-labeled lipoplex nanosystem for image-guided gene delivery: design, evaluation of stability and in vivo behavior

I Hajdu, A Makhlouf, VR Solomon… - International journal …, 2018 - Taylor & Francis
Background With the advances in radiopharmaceutical research, the development of image-
guided therapy has become a major interest. While the development of theranostic …