Targeting the B cell receptor pathway in chronic lymphocytic leukemia

MS Davids, JR Brown - Leukemia & lymphoma, 2012 - Taylor & Francis
The B cell receptor (BCR) pathway plays a crucial role in the survival, proliferation and
trafficking of chronic lymphocytic leukemia (CLL) cells. Inhibitors of the key kinases in this …

Targeting PD-L1/PD-1-mediated inhibitory signaling with BTK inhibitors in Chronic Lymphocytic Leukemia (CLL).

MA Schwarzbich - 2020 - qmro.qmul.ac.uk
Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in adults in the West. An
unmet need for equally curative and tolerable treatment approaches exists. Our group has …