Exosome-based immunotherapy: a promising approach for cancer treatment

Z Xu, S Zeng, Z Gong, Y Yan - Molecular cancer, 2020 - Springer
In the era of the rapid development of cancer immunotherapy, there is a high level of interest
in the application of cell-released small vesicles that stimulate the immune system. As cell …

[HTML][HTML] Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics

A Thakur, DC Parra, P Motallebnejad, M Brocchi… - Bioactive materials, 2022 - Elsevier
Cancer is a deadly disease that is globally and consistently one of the leading causes of
mortality every year. Despite the availability of chemotherapy, radiotherapy, immunotherapy …

Exosome-based vaccines: history, current state, and clinical trials

P Santos, F Almeida - Frontiers in immunology, 2021 - frontiersin.org
Extracellular vesicles (EVs) are released by most cell types as part of an intracellular
communication system in crucial processes such as inflammation, cell proliferation, and …

Hypoxia induced changes of exosome cargo and subsequent biological effects

H Jiang, H Zhao, M Zhang, Y He, X Li, Y Xu… - Frontiers in …, 2022 - frontiersin.org
Exosomes are small extracellular vesicles that are secreted by almost all types of cells and
exist in almost all extracellular spaces. As an important mediator of intercellular …

Exosome as a delivery vehicle for cancer therapy

B Moon, S Chang - Cells, 2022 - mdpi.com
Exosomes are small extracellular vesicles that are naturally produced and carry
biomolecules such as proteins, microRNAs, and metabolites. Because of their small size …

[HTML][HTML] Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human …

S Ye, ZL Li, D Luo, B Huang, YS Chen, X Zhang, J Cui… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Tumor-derived exosomes contain biologically active proteins and messenger and
microRNAs (miRNAs). These particles serve as vehicles of intercellular communication and …

Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomes

I Nakase, NB Kobayashi, T Takatani-Nakase… - Scientific reports, 2015 - nature.com
Exosomes are approximately 100-nm vesicles that consist of a lipid bilayer of cellular
membranes secreted in large quantities from various types of normal and disease-related …

Formation and role of exosomes in cancer

LT Brinton, HS Sloane, M Kester, KA Kelly - Cellular and molecular life …, 2015 - Springer
Exosomes offer new insight into cancer biology with both diagnostic and therapeutic
implications. Because of their cell-to-cell communication, exosomes influence tumor …

The roles of small extracellular vesicles in cancer and immune regulation and translational potential in cancer therapy

K Qian, W Fu, T Li, J Zhao, C Lei, S Hu - Journal of Experimental & Clinical …, 2022 - Springer
Extracellular vesicles (EVs) facilitate the extracellular transfer of proteins, lipids, and nucleic
acids and mediate intercellular communication among multiple cells in the tumour …

[HTML][HTML] Exosome regulation of immune response mechanism: Pros and cons in immunotherapy

JM Essola, M Zhang, H Yang, F Li, B Xia… - Bioactive Materials, 2024 - Elsevier
Due to its multiple features, including the ability to orchestrate remote communication
between different tissues, the exosomes are the extracellular vesicles arousing the highest …