In the present study, a novel series of 4-pyrrol-1-yl benzoic acid hydrazide analogs, some
derived 5-substituted-2-thiol-1, 3, 4-oxadiazoles, 5-substituted-4-amino-1, 2, 4-triazolin-3 …

Several 3, 6-disubstituted-1, 2, 4-triazolo-[3, 4-b]-1, 3, 4-thiadiazoles were prepared by
condensation of 4-amino-5-substituted-3-mercapto-(4H)-1, 2, 4-triazoles (3a, b) with various …

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Substituted-1, 2, 4-triazole-5-thiones are versatile synthetic intermediates for the preparation
of several biologically active N-bridged heterocyclic compounds, given that they have two …

The aim of the study was a synthesis and investigation of the dose-dependent anti-
inflammatory effect of new thiourea derivatives of naproxen with selected aromatic amines …

A series of thiazolo [3, 2-b][1, 2, 4] triazole incorporating diphenylsulfone moieties were
synthesized starting from 5-[4-(4-X-phenylsulfonyl) phenyl]-4H-1, 2, 4-triazole-3-thioles 3a …

Combating several pathological conditions associated with ureolytic enzyme (urease)
remains a formidable challenge because of the lack of effective and safe drug therapies. In …

Starting from 3-substituted-1, 2, 4-triazole-5-thiones (1a–h), eight new 5-carbomethoxy-2-
substituted-7H-1, 2, 4-triazolo [3, 2-b]-1, 3-thiazine-7-ones (2a–h) were synthesized and …

In an effort to establish new candidates with improved analgesic and anti-inflammatory
activities and lower ulcerogenic risk, a series of thiazolo [3, 2-b]-1, 2, 4-triazole-5 (6H)-one …

The present paper is devoted to the search for drug-like molecules with anticancer
properties using the thiazolo [3, 2-b][1, 2, 4] triazole-6-one scaffold. A series of 24 novel …