Adrenomedullin (ADM) is a peptide hormone first discovered in 1993 in pheochromocytoma.
It is synthesized by endothelial and vascular smooth muscle cells and diffuses freely …

Heart failure (HF) biomarkers have dramatically impacted the way HF patients are evaluated
and managed. B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) are the …

Heart Failure Society (JHFS). The working committee for this project includes members and
collaborators involved in the previous versions of the heart failure guidelines and members …

Heart failure results not only from cardiac overload or injury but also from a complex
interplay among genetic, neurohormonal, inflammatory, and biochemical changes acting on …

This review summarizes the receptor-mediated vascular activities of calcitonin gene-related
peptide (CGRP) and the structurally related peptide adrenomedullin (AM). CGRP is a 37 …

Background—Pluripotent mesenchymal stem cells (MSCs) differentiate into a variety of cells,
including cardiomyocytes and vascular endothelial cells. However, little information is …

Background: Patients with left ventricular (LV) systolic dysfunction after myocardial infarction
are at a high risk of developing heart failure. The addition of neprilysin inhibition to renin …

The volume of extracellular fluid (ECF) is maintained within narrow limits in normal human
subjects, despite day-to-day variations in dietary intake of salt and water over a wide range …

Abstract The PARADIGM-HF (Prospective comparison of ARNi with ACEi to Determine
Impact on Global Mortality and Morbidity in Heart Failure) trial demonstrated that a new …

The majority of end-stage renal disease (ESRD) patients are hypertensive. Hypertension in
the hemodialysis patient population is multifactorial. Further, hypertension is associated with …