Activated fibroblasts in tumors, or cancer-associated fibroblasts (CAFs), have become a
popular research area over the past decade. As important players in many aspects of tumor …

Cancer progression often benefits from the selective conditions present in the tumour
microenvironment, such as the presence of cancer-associated fibroblasts (CAFs) …

Liver metastasis of colorectal cancer (CRLM) is the most common cause of CRC‐related
mortality, and is typically caused by interactions between CRC cells and the tumour …

Among all cells, fibroblasts could be considered the cockroaches of the human body. They
survive severe stress that is usually lethal to all other cells, and they are the only normal cell …

Cancer stem cells (CSCs) are tumor cells that have the principal properties of self-renewal,
clonal tumor initiation capacity, and clonal long-term repopulation potential. CSCs reside in …

Tumours are known as wounds that do not heal—this implies that cells that are involved in
angiogenesis and the response to injury, such as endothelial cells and fibroblasts, have a …

The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

The'seed and soil'hypothesis for metastasis sets forth the concept that a conducive
microenvironment, or niche, is required for disseminating tumour cells to engraft distant …

Cancer-associated fibroblasts (CAFs) provide critical metabolites for tumor growth and
undergo metabolic reprogramming to support glycolysis. However, the molecular …

TGF-beta signaling is one of the major pathways controlling cell and tissue behavior not only
in homeostasis but also in disease. During tumorigenesis TGF-beta orchestrated processes …