[HTML][HTML] Tumor mutation burden for predicting immune checkpoint blockade response: the more, the better

M Zheng - Journal for immunotherapy of cancer, 2022 - ncbi.nlm.nih.gov
Background Recently, the US Food and Drug Administration (FDA) has approved immune
checkpoint blockade (ICB) for treating cancer patients with tumor mutation burden (TMB)> …

The lung cancers: staging and response, CT, 18F-FDG PET/CT, MRI, DWI: review and new perspectives

C Owens, S Hindocha, R Lee, T Millard… - The British Journal of …, 2023 - academic.oup.com
Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer
deaths in both sexes combined. Recent years have seen major advances in the diagnostic …

Advanced Diffusion‐Weighted MRI for Cancer Microstructure Assessment in Body Imaging, and Its Relationship With Histology

E Fokkinga, JA Hernandez‐Tamames… - Journal of Magnetic …, 2023 - Wiley Online Library
Diffusion‐weighted magnetic resonance imaging (DW‐MRI) aims to disentangle multiple
biological signal sources in each imaging voxel, enabling the computation of innovative …

Detecting cellular microstructural changes of liver fibrosis with time-dependent diffusion MRI

L Zhang, X Long, L Chen, X Han, X Zhang, P Sun… - Radiology, 2024 - pubs.rsna.org
Background The potential of time-dependent diffusion MRI in imaging the progression from
liver fibrosis to cirrhosis has not been established. Purpose To assess the effectiveness of …

Granzyme B PET imaging of combined chemotherapy and immune checkpoint inhibitor therapy in colon cancer

JL Goggi, SV Hartimath, TY Xuan, S Khanapur… - Molecular Imaging and …, 2021 - Springer
Purpose Chemotherapeutic adjuvants, such as oxaliplatin (OXA) and 5-fluorouracil (5-FU),
that enhance the immune system, are being assessed as strategies to improve durable …

Multiparametric MRI for characterization of the tumour microenvironment

E Hoffmann, M Masthoff, WG Kunz… - Nature Reviews …, 2024 - nature.com
Our understanding of tumour biology has evolved over the past decades and cancer is now
viewed as a complex ecosystem with interactions between various cellular and non-cellular …

[HTML][HTML] Profiling specific cell populations within the inflammatory tumor microenvironment by oscillating-gradient diffusion-weighted MRI

E Hoffmann, M Gerwing, S Niland… - … for Immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background The inflammatory tumor microenvironment (TME) is formed by various immune
cells, being closely associated with tumorigenesis. Especially, the interaction between tumor …

Improving MR cell size imaging by inclusion of transcytolemmal water exchange

X Jiang, SP Devan, J Xie, JC Gore, J Xu - NMR in Biomedicine, 2022 - Wiley Online Library
The goal of the current study is to include transcytolemmal water exchange in MR cell size
imaging using the IMPULSED model for more accurate characterization of tissue cellular …

Systems immunology spanning tumors, lymph nodes, and periphery

DN Sidiropoulos, WJ Ho, EM Jaffee, LT Kagohara… - Cell Reports …, 2023 - cell.com
The immune system defines a complex network of tissues and cell types that orchestrate
responses across the body in a dynamic manner. The local and systemic interactions …

The Era of Immunotherapy in Hepatocellular Carcinoma: The New Mission and Challenges of Magnetic Resonance Imaging

Y Chen, C Yang, L Sheng, H Jiang, B Song - Cancers, 2023 - mdpi.com
Simple Summary Clinicians should be aware that the immune microenvironment not only
influences biological characteristics of HCC but also provides a reliable theoretical basis for …