Mechanical loads are vital regulators of skeletal mass and architecture as evidenced by the
increase in bone formation following the addition of exogenous loads and loss of bone mass …

Microfluidic-based tissue-on-a-chip devices have generated significant research interest for
biomedical applications, such as pharmaceutical development, as they can be used for …

Recent studies have confirmed that microRNAs and lncRNAs can affect bone cell
differentiation and bone formation. In this study, miR-139-3p was upregulated in the femurs …

Perfusion culture of osteoprogenitor cells seeded within porous scaffolds suitable for bone
tissue engineering is known to enhance deposition of a bone-like extracellular matrix, and …

In this study, porcine bone collagen peptide (CP) was phosphorylated with sodium tripoly
phosphate (STP) in order to improve its calcium binding capacity and osteogenic activity …

Type I collagen (COL I) and matrix metalloproteinase-1 (MMP-1) are the predominant matrix
proteins in the extracellular matrix of the human periodontal ligament (PDL). The expression …

The characteristics of dilated cardiomyopathy (DCM) resulting from chronic viral myocarditis
are remodeling processes of the extracellular matrix. Based on our findings of enhanced …

Osteogenesis imperfecta (OI) is a primary bone fragility disorder with an estimated
prevalence of 1 in 15,000 births. The majority of OI cases are inherited in an autosomal …

Interstitial flow in and around bone tissue is oscillatory in nature and affects the mechanical
microenvironment for bone cell growth and formation. We investigated the role of oscillatory …

A medium perfusion system is expected to be beneficial for three‐dimensional (3D) culture
of engineered bone, not only by chemotransport enhancement but also by mechanical …