The thin and thick filaments of muscle sarcomeres are interconnected by the giant protein
titin, which is a scaffolding filament, signaling platform, and provider of passive tension and …

The Frank–Starling law of the heart describes the interrelationship between end-diastolic
volume and cardiac ejection volume, a regulatory system that operates on a beat-to-beat …

Covering everything from historical and international perspectives to basic science and
current clinical practice, Miller's Anesthesia, 9th Edition, remains the preeminent reference in …

We develop a point model of the cardiac myofilament (MF) to simulate a wide variety of
experimental muscle characterizations including Force-Ca relations and twitches under …

The sarcomeric proteins represent the structural building blocks of heart muscle, which are
essential for contraction and relaxation. During recent years, it has become evident that …

Biomedical research is at a critical point at present. The research has led to an enormous
amount of data and models describing these data, but-proachesforapplication …

Two groundbreaking papers published in 1954 laid out the theory of the mechanism of
muscle contraction based on force-generating interactions between myofilaments in the …

The determinants of relaxation in cardiac muscle are poorly understood, yet compromised
relaxation accompanies various pathologies and impaired pump function. In this study, we …

SUMMARY The Frank–Starling law of the heart applies to all classes of vertebrates. It
describes how stretch of cardiac muscle, up to an optimum length, increases contractility …

The giant elastic protein titin contains a molecular spring segment that underlies the majority
of myocardial passive stiffness. The mechanical characteristics of this spring may be tuned …