The translationally controlled tumour protein (TCTP)

UA Bommer, BJ Thiele - The international journal of biochemistry & cell …, 2004 - Elsevier
The translationally controlled tumour protein (TCTP) is a highly conserved protein that is
widely expressed in all eukaryotic organisms. Based on its sequence, TCTP was listed as a …

Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells

T Efferth - Current drug targets, 2006 - ingentaconnect.com
Secondary metabolites from plants can serve as defense against herbivores, microbes,
viruses or competing plants. Many compounds from medicinal plants have pharmacological …

Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes

A Xu, KW Chan, RLC Hoo, Y Wang, KCB Tan… - Journal of Biological …, 2005 - ASBMB
The antidiabetic hormone adiponectin circulates in blood as several oligomeric complexes,
and the ratios between them are critical in determining insulin sensitivity. In this study we …

TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway

N Amzallag, BJ Passer, D Allanic, E Segura… - Journal of Biological …, 2004 - ASBMB
Translationally controlled tumor protein (TCTP) is cytoplasmic and structurally related to
guanine-nucleotide free chaperones. TCTP (also called histamine-releasing factor) has …

Translationally controlled tumor protein acts as a guanine nucleotide dissociation inhibitor on the translation elongation factor eEF1A

C Cans, BJ Passer, V Shalak… - Proceedings of the …, 2003 - National Acad Sciences
Recently, we demonstrated that the expression levels of the translationally controlled tumor
protein (TCTP) were strongly down-regulated at the mRNA and protein levels during tumor …

Structure of TCTP reveals unexpected relationship with guanine nucleotide-free chaperones

P Thaw, NJ Baxter, AM Hounslow, C Price… - Nature structural …, 2001 - nature.com
The translationally controlled tumor-associated proteins (TCTPs) are a highly conserved and
abundantly expressed family of eukaryotic proteins that are implicated in both cell growth …

TCTP as therapeutic target in cancers

J Acunzo, V Baylot, A So, P Rocchi - Cancer treatment reviews, 2014 - Elsevier
The translationally controlled tumor protein (TCTP) is a highly conserved protein present in
eukaryotic organisms. This protein, located both in the cytoplasmic and the nucleus, is …

Rotavirus NSP4: a multifunctional viral enterotoxin

JM Ball, DM Mitchell, TF Gibbons, RD Parr - Viral immunology, 2005 - liebertpub.com
ROTAVIRUS NONSTRUCTURAL PROTEIN 4 (NSP4) en-coded by gene 10 is the first
described viral enterotoxin (7). Since the report of the NSP4 toxic activity, identification of …

Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice—a model of familial amyotrophic lateral sclerosis

HF Poon, K Hensley, V Thongboonkerd… - Free Radical Biology …, 2005 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron degenerative disease
characterized by the loss of neuronal function in the motor cortex, brain stem, and spinal …

The mRNA of the translationally controlled tumor protein P23/TCTP is a highly structured RNA, which activates the dsRNA-dependent protein kinase PKR

UA Bommer, AV Borovjagin, MA Greagg, IW Jeffrey… - Rna, 2002 - cambridge.org
The dsRNA-activated protein kinase PKR is involved in signal transduction pathways that
mediate cellular processes as diverse as cell growth and differentiation, the stress response …