Pregnancy entails a large negative balance of iron, an essential micronutrient. During
pregnancy, iron requirements increase substantially to support both maternal red blood cell …

Iron is a vital element in nearly every living organism. During pregnancy, optimal iron
concentration is essential for both maternal health and fetal development. As the barrier …

The human placenta is a highly specialized organ that is responsible for housing, protecting,
and nourishing the fetus across gestation. The placenta is essential as it functions among …

Background Iron plays a crucial role through various life stages of human. Iron homeostasis
is primarily regulated by iron absorption which is mediated via divalent metal-ion transporter …

Fetal development relies on adequate iron supply by the placenta. The placental
syncytiotrophoblasts (SCTB) express high levels of iron transporters, including ferroportin1 …

Background Murine data suggest that the placenta downregulates ferroportin (FPN) when
iron is limited to prioritize iron for its own needs. Human data on the impact of maternal and …

Mouse trophoblast stem (mTS) cells can be derived from the blastocyst or extraembryonic
ectoderm as late as embryonic day (E) 6.5 and when cultured in vitro, can differentiate to all …

In pigs, iron deficiency anemia (IDA) is a common disorder that occurs during the early
postnatal period, leading to the stunted growth and increased mortality of piglets. The main …

Purpose Adequate iron transportation from the mother across the placenta is crucial for fetal
growth and establishing sufficient iron stores in neonates at birth. The past decade has …