Autism spectrum disorder (ASD) is an increasingly prevalent neurodevelopmental disorder
with considerable clinical heterogeneity. With no cure for the disorder, treatments commonly …

Neural development requires the orchestration of dynamic changes in gene expression to
regulate cell fate decisions. This regulation is heavily influenced by epigenetics, heritable …

Epigenetics, one mechanism by which gene expression can change without any changes to
the DNA sequence, was described nearly a century ago. However, the importance of …

In mammalian cells, the SET1/MLL complexes are the main writers of the H3K4 methyl mark
that is associated with active gene expression. The activities of these complexes are …

Few neuropsychiatric disorders have replicable biomarkers, prompting high-resolution and
large-scale molecular studies. However, we still lack consensus on a more foundational …

Bisphenol A (BPA), one of the chemicals with the highest volume of production worldwide,
has been demonstrated to cause testicular toxicity via different pathways. However, there is …

Abstract WD-repeat domain 5 (WDR5), a core component of histone methyltransferase
complexes, is associated with Kabuki syndrome and Kleefstra syndrome that feature …

Therapeutic hypothermia (TH) is well established as a standard treatment for term and near-
term infants. However, therapeutic effects of hypothermia following neonatal anoxia in very …

It remains largely unclear how stem cells regulate bioenergetics and genome integrity to
ensure tissue homeostasis. Here, our integrative gene analyses suggest that metabolic and …

DPY30 belongs to the core subunit of components of the histone lysine methyltransferase
complex, which is implicated in tumorigenesis, cell senescence, and other biological events …