Genetic loss-of-function studies on development, cancer and somatic cell reprogramming
have suggested that the group of macroH2A histone variants might function through …

Onset of castration-resistance prostate cancer (CRPC) after long-term androgen deprivation
therapy remains a major obstacle in the treatment of prostate cancer. The peptidylarginine …

MacroH2A histone variants suppress tumor progression and act as epigenetic barriers to
induced pluripotency. How they impart their influence on chromatin plasticity is not well …

Histone variants are structural components of eukaryotic chromatin that can replace
replication-coupled histones in the nucleosome. The histone variant macroH2A1. 1 contains …

Mesenchymal stromal cell-derived extracellular vesicles (MSC-EV) are widely considered as
a cell-free therapeutic alternative to MSC cell administration, due to their immunomodulatory …

The caudal-related homeobox protein 1 (CDX1) is a transcription factor, which is important
in the development, differentiation, and homeostasis of the gut. Although the involvement of …

Peptidyl arginine deiminases (PADI) are a family of enzymes that catalyze the poorly
understood posttranslational modification converting arginine residues into citrullines. In this …

Opinion statement The capacity of cells to modify their phenotypes from epithelial to
mesenchymal (epithelial-to-mesenchymal transition or EMT) and vice versa provides them …

MacroH2A histone variants have a function in gene regulation that is poorly understood at
the molecular level. We report that macroH2A1. 2 and macroH2A2 modulate the …

Mesenchymal stromal cells (MSCs) have been considered as one of the pivotal type of cells
composing the tumor microenvironment. Although contact-dependent mechanisms and …