[PDF][PDF] Looking beneath the surface: the importance of subcortical structures in frontotemporal dementia
Whilst initial anatomical studies of frontotemporal dementia focussed on cortical
involvement, the relevance of subcortical structures to the pathophysiology of frontotemporal …
involvement, the relevance of subcortical structures to the pathophysiology of frontotemporal …
Advances in the treatment and management of frontotemporal dementia
Introduction Frontotemporal dementia (FTD) is a complex neurodegenerative disorder,
characterized by a wide range of pathological conditions associated with the buildup of …
characterized by a wide range of pathological conditions associated with the buildup of …
Thalamic nuclei atrophy at high and heterogenous rates during cognitively unimpaired human aging
The thalamus is a central integration structure in the brain, receiving and distributing
information among the cerebral cortex, subcortical structures, and the peripheral nervous …
information among the cerebral cortex, subcortical structures, and the peripheral nervous …
Neurodevelopmental effects of genetic frontotemporal dementia in young adult mutation carriers
While frontotemporal dementia has been considered a neurodegenerative disease that
starts in mid-life or later, it is now clearly established that cortical and subcortical volume loss …
starts in mid-life or later, it is now clearly established that cortical and subcortical volume loss …
Longitudinal Effects of Asymptomatic C9orf72 Carriership on Brain Morphology
K van Veenhuijzen, HJ Westeneng… - Annals of …, 2023 - Wiley Online Library
Objective We investigated effects of C9orf72 repeat expansion and gene expression on
longitudinal cerebral changes before symptom onset. Methods We enrolled 79 …
longitudinal cerebral changes before symptom onset. Methods We enrolled 79 …
TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss
Abstract TMEM106B, a type II lysosomal transmembrane protein, has recently been
associated with brain aging, hypomyelinating leukodystrophy, frontotemporal lobar …
associated with brain aging, hypomyelinating leukodystrophy, frontotemporal lobar …
Temporal order of clinical and biomarker changes in familial frontotemporal dementia
AM Staffaroni, M Quintana, B Wendelberger… - Nature medicine, 2022 - nature.com
Unlike familial Alzheimer's disease, we have been unable to accurately predict symptom
onset in presymptomatic familial frontotemporal dementia (f-FTD) mutation carriers, which is …
onset in presymptomatic familial frontotemporal dementia (f-FTD) mutation carriers, which is …
Thalamic pathology in frontotemporal dementia: predilection for specific nuclei, phenotype‐specific signatures, clinical correlates, and practical relevance
MC McKenna, J Lope, P Bede, EL Tan - Brain and Behavior, 2023 - Wiley Online Library
Background Frontotemporal dementia (FTD) phenotypes are classically associated with
distinctive cortical atrophy patterns and regional hypometabolism. However, the spectrum of …
distinctive cortical atrophy patterns and regional hypometabolism. However, the spectrum of …
Anatomical MRI staging of frontotemporal dementia variants
INTRODUCTION The three clinical variants of frontotemporal dementia (behavioral variant
[bvFTD], semantic dementia, and progressive non‐fluent aphasia [PNFA]) are likely to …
[bvFTD], semantic dementia, and progressive non‐fluent aphasia [PNFA]) are likely to …
Classifying Alzheimer's disease and frontotemporal dementia using machine learning with cross‐sectional and longitudinal magnetic resonance imaging data
A Pérez‐Millan, J Contador… - Human brain …, 2023 - Wiley Online Library
Alzheimer's disease (AD) and frontotemporal dementia (FTD) are common causes of
dementia with partly overlapping, symptoms and brain signatures. There is a need to …
dementia with partly overlapping, symptoms and brain signatures. There is a need to …