Dry eye can damage the ocular surface and result in mild corneal epithelial defect to
blinding corneal pannus formation and squamous metaplasia. Significant progress in the …

Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 27-or 38-amino acid
neuropeptide, which belongs to the vasoactive intestinal polypeptide (VIP)/glucagon …

Dry eye disease (DED) impacts≈ 30% of the world's population and causes serious ocular
discomfort and even visual impairment. Inflammation is one core cause of the DED vicious …

Ocular surface neovascularization and its resulting pathological changes significantly alter
corneal refraction and obstruct light path to the retina, and hence is a major cause of vision …

The transparency of the cornea along with its dense sensory innervation and resident
leukocyte populations make it an ideal tissue to study interactions between the nervous and …

Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide widely
distributed in the nervous system, where it exerts strong neuroprotective effects. PACAP is …

Dry eye disease (DED) is a prevalent ocular disorder characterized by unstable tear film
condition with loss of aqueous or mucin, excessive oxidative stress, and inflammation …

Pituitary Adenylate Cyclase-Activating Peptide (PACAP) and Vasoactive Intestinal Peptide
(VIP) are neuropeptides involved in a diverse array of physiological and pathological …

A bidirectional cross-talk is established between the nervous and immune systems through
common mediators including neuropeptides, neurotransmitters, and cytokines. Among …

Aquaporin 5 (AQP5) plays an important role in the salivary gland function. The mRNA and
protein for AQP5 are expressed in the acini from embryonic days E13-16 and E17-18 …