Podosomes and invadopodia are unique actin-rich adhesions that establish close contact to
the substratum but can also degrade components of the extracellular matrix. Accordingly …

Invadopodia and podosomes are discrete, actin‐based molecular protrusions that form in
cancer cells and normal cells, respectively, in response to diverse signaling pathways and …

Remodeling of extracellular matrix (ECM) is a fundamental cell property that allows cells to
alter their microenvironment and move through tissues. Invadopodia and podosomes are …

Rho family GTPases control cell migration and participate in the regulation of cancer
metastasis. Invadopodia, associated with invasive tumour cells, are crucial for cellular …

Osteoclasts are multinucleated cells that are responsible for resorption of bone, and
increased activity of these cells is associated with several common bone diseases, including …

Cell–matrix adhesions are essential for cell migration, tissue organization and
differentiation, therefore playing central roles in embryonic development, remodeling and …

The Rho family GTPase Cdc42 regulates cytoskeletal organization and membrane
trafficking in physiological processes such as cell proliferation, motility and polarity. Aberrant …

Asthma is characterized by airway hyperresponsiveness and airway remodeling, which are
largely attributed to increased airway smooth muscle contractility and cell proliferation. It is …

We have previously performed an unbiased screen to identify genes whose expression is
associated with the metastatic phenotype. Secondary screening of these genes using …

Cell invasion is a highly complex process that requires the coordination of cell migration and
degradation of the extracellular matrix. In melanoma cells, as in many highly invasive cancer …