Molecules | Free Full-Text | Synthetic Approaches and Pharmacological Activity of 1,3,4-Oxadiazoles:
A Review of the Literature from 2000–2012 Next Article in Journal Chemical Composition of …

Understanding the factors that promote drug innovation is important both for improvements
in health care and for the future of organizations engaged in drug discovery research and …

The acetylcholinesterase and carbonic anhydrase inhibitors (AChEIs and h CAIs) remain
key therapeutic agents for many bioactivities such as anti-Alzheimer and antiobesity …

The concept of isosterism between relatively simple chemical entities was originally
contemplated by James Moir in 1909, a notion further refined by HG Grimm's hydride …

Background Raltegravir (MK-0518) is an inhibitor of human immunodeficiency virus type 1
(HIV-1) integrase active against HIV-1 susceptible or resistant to older antiretroviral drugs …

Montmorillonite is one of the most intensively explored catalytic materials in heterogeneous
catalysis due to its low cost and eco-friendliness. Also, it possesses some unique properties …

For more than two decades, chloroquine (CQ) was largely and deliberately used as first
choice drug for malaria treatment. However, worldwide increasing cases of resistant strains …

tert-Butoxy-(4-phenyl-quinolin-3-yl)-acetic acids (tBPQA) are a new class of HIV-1 integrase
(IN) inhibitors that are structurally distinct from IN strand transfer inhibitors but analogous to …

In spite of its recent achievements, the technique of single particle electron cryomicroscopy
(cryoEM) has not been widely used to study proteins smaller than 100 kDa, although it is a …

In order to minimize expensive drug failures, is essential to determine potential activity,
toxicity and ADME problems as early as possible. In view of the large libraries of compounds …