Recent advances in the structural library of functionalized quinazoline and quinazolinone scaffolds: Synthetic approaches and multifarious applications

I Khan, A Ibrar, N Abbas, A Saeed - European Journal of Medicinal …, 2014 - Elsevier
Drug development has been a principal driving force in the rapid maturation of the field of
medicinal chemistry during the past several decades. During this period, the intriguing and …

[PDF][PDF] Metal complexes as potential antimicrobial agent: a review

MS Hossain, CM Zakaria… - American Journal of …, 2018 - researchgate.net
Metal ions play many critical functions in humans. Deficiency of some metal ions can lead to
disease like pernicious anemia resulting from iron deficiency, growth retardation arising from …

New Bis(pyrazolo[5,1‐b]quinazolines) and Bis(9H‐xanthenediones) Linked to Alkane Cores: One‐Pot Synthesis, Antibacterial Screening, and SAR Study

AEM Mekky, SMH Sanad - Chemistry & Biodiversity, 2024 - Wiley Online Library
Effective one‐pot methods were used to synthesize some new alkane‐linked bis (pyrazolo
[5, 1‐b] quinazolines) and bis (9H‐xanthenediones). The first series was produced, in 80 …

Novel fluorinated pyrazole-based heterocycles scaffold: cytotoxicity, in silico studies and molecular modelling targeting double mutant EGFR L858R/T790M as …

EA Fayed, NA Gohar, AH Bayoumi… - Medicinal Chemistry …, 2023 - Springer
Hepatocellular carcinoma (HCC), also known as hepatoma, is the most prevalent type of
primary liver cancer. It begins in the hepatocytes, the liver's major cell type. Cancer that …

A novel quinazoline-4-one derivatives as a promising cytokine inhibitors: Synthesis, molecular docking, and structure-activity relationship

RM Borik, MA Hussein - Current Pharmaceutical Biotechnology, 2022 - ingentaconnect.com
Background: Quinazolines are a common class of nitrogen-containing heterocyclic scaffolds,
which exhibit a broad spectrum of pharmacological activities. Objectives: In the present …

Design, synthesis, and biological evaluation of new pyrazoloquinazoline derivatives as dual COX‐2/5‐LOX inhibitors

MA Shaaban, AM Kamal, SI Faggal… - Archiv der …, 2020 - Wiley Online Library
A new series of pyrazoloquinazoline derivatives equipped with different chalcones was
designed, synthesized, and identified through 1H nuclear magnetic resonance (NMR), 13C …

Antioxidant and antimicrobial activities of novel quinazolinones

AA Al-Amiery, AAH Kadhum, M Shamel, M Satar… - Medicinal Chemistry …, 2014 - Springer
The antimicrobial and antioxidant activities of quinazolinones have widely been studied.
However, there have been no studies on the antimicrobial and antioxidant activities of …

New fused pyrazolopyrimidine derivatives; heterocyclic styling, synthesis, molecular docking and anticancer evaluation

AY Hassan, NM Saleh, MS Kadh… - Journal of …, 2020 - Wiley Online Library
Novel pyrazolopyrimidines and their fused derivatives derived from aminopyrazole moiety
as pyrazoloquinazoline, chromenopyrazolopyrimidine, pyrazolopyrimidopyrimidine …

Antioxidant, cytotoxic, genotoxic, and DNA-protective potential of 2, 3-substituted quinazolinones: Structure—Activity relationship study

J Hricovíniová, Z Hricovíniová, K Kozics - International Journal of …, 2021 - mdpi.com
The evaluation of antioxidant compounds that counteract the mutagenic effects caused by
the direct action of reactive oxygen species on DNA molecule is of considerable interest …

Novel nickel (II) and copper (II) coordination compounds of 2–phenylquinazoline–4–carboxylate: Synthesis and characterization

N Büyükkıdan, D Gök, H İlkimen, M Sarı - Journal of Molecular Structure, 2023 - Elsevier
Two novel compounds [Ni (PQC) 2 (H 2 O) 2]. H 2 O and [Cu (PQC) 2] where PQC= 2–
phenylquinazoline–4–carboxylate have been synthesized. Magnetic susceptibility …