Betulinic acid (BA) is a pentacyclic triterpene compound that can be obtained by separation,
chemical synthesis and biotransformation from birch. BA has antitumour activity, and its …

The mammalian brain consists of millions to billions of cells that are organized into many cell
types with specific spatial distribution patterns and structural and functional properties …

Krüppel-like factors (KLFs) are a family of zinc-finger transcription factors that are found in
many species. Recent studies have shown that KLFs play a fundamental role in regulating …

Viral infection outcomes are sex biased, with males generally more susceptible than
females. Paradoxically, the numbers of antiviral natural killer (NK) cells are increased in …

A widely held—but rarely tested—hypothesis for the origin of animals is that they evolved
from a unicellular ancestor, with an apical cilium surrounded by a microvillar collar, that …

Sepsis is a heterogeneous syndrome induced by a dysregulated host response to infection.
Glycolysis plays a role in maintaining the immune function of macrophages, which is crucial …

Cerebral cavernous malformations (CCM s) are vascular malformations located within the
central nervous system often resulting in cerebral hemorrhage. Pharmacological treatment is …

Tumor development and progression depend on reprogramming of signaling pathways that
regulate cell metabolism. Alterations to various metabolic pathways such as glycolysis …

Specificity proteins (SPs) and Krüppel-like factors (KLFs) belong to the family of transcription
factors that contain conserved zinc finger domains involved in binding to target DNA …

Corals respond to heat pulses that cause bleaching with massive transcriptional change, but
the immediate responses to stress that lead up to these shifts have never been detailed …