It has been observed that some non-steroidal anti-inflammatory drugs (NSAIDs) may act
through several mechanisms, in addition to central inhibition of prostaglandin synthesis …

Combinations of analgesics with different mechanisms of action offer the possibility of
efficient analgesia with a decrease in side effects as a result of reduced dosages of one or …

Synergism has been used to obtain analgesia at doses at which side effects are minimal. In
addition, it has been demonstrated that inhibition of cyclooxygenase-2 is responsible for the …

The purpose of the present study was to determine whether caffeine modifies the
pharmacokinetics and pharmacodynamics of (S)-ketoprofen following oral administration in …

It has been observed that caffeine improves antinociceptive efficacy of some non-steroidal
antiinflammatory drugs (NSAIDs) in several experimental models, however, these effects …

The spinal activity of racemic ketoprofen and its enantiomers in models of neuropathic and
tonic pain was explored in rats. Tactile allodynia and thermal hyperalgesia were induced by …

Pain‐induced functional impairment in the rat (PIFIR) is a model of inflammatory and arthritic
pain similar to that of clinical gout. Nociception is induced by the intra‐articular injection of …

Objective and design The gastric toxicity of racemic-ketoprofen and its enantiomers (S (+)−
and R (−)− ketoprofen), oxygen free radical generation and neutrophil infiltration in response …

The objective of this study was to compare the recovery of male rats after a major abdominal
surgical procedure (the implantation of a radiotelemetry transmitter) when treated with …

Nonsteroidal antiinflammatory drugs (NSAIDs) inhibit prostaglandin synthesis in the
gastrointestinal mucosa, which can lead not only to stomach ulcers but also ulcers in the …