SCFTIR1/AFB-Based Auxin Perception: Mechanism and Role in Plant Growth and Development
Auxin regulates a vast array of growth and developmental processes throughout the life
cycle of plants. Auxin responses are highly context dependent and can involve changes in …
cycle of plants. Auxin responses are highly context dependent and can involve changes in …
Eukaryotic DNA replication fork
PMJ Burgers, TA Kunkel - Annual review of biochemistry, 2017 - annualreviews.org
This review focuses on the biogenesis and composition of the eukaryotic DNA replication
fork, with an emphasis on the enzymes that synthesize DNA and repair discontinuities on the …
fork, with an emphasis on the enzymes that synthesize DNA and repair discontinuities on the …
Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation
The eukaryotic CMG (Cdc45, Mcm2–7, GINS) helicase consists of the Mcm2–7 hexameric
ring along with five accessory factors. The Mcm2–7 heterohexamer, like other hexameric …
ring along with five accessory factors. The Mcm2–7 heterohexamer, like other hexameric …
Rescuing stalled or damaged replication forks
JTP Yeeles, J Poli, KJ Marians… - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
In recent years, an increasing number of studies have shown that prokaryotes and
eukaryotes are armed with sophisticated mechanisms to restart stalled or collapsed …
eukaryotes are armed with sophisticated mechanisms to restart stalled or collapsed …
MCM: one ring to rule them all
TD Deegan, JFX Diffley - Current opinion in structural biology, 2016 - Elsevier
Highlights•The eukaryotic MCM replicative helicase is tightly regulated during the cell
cycle.•Conformational changes in MCM underpin the different stages of chromosome …
cycle.•Conformational changes in MCM underpin the different stages of chromosome …
Replication fork activation is enabled by a single-stranded DNA gate in CMG helicase
MR Wasserman, GD Schauer, ME O'Donnell, S Liu - Cell, 2019 - cell.com
The eukaryotic replicative helicase CMG is a closed ring around double-stranded (ds) DNA
at origins yet must transition to single-stranded (ss) DNA for helicase action. CMG must also …
at origins yet must transition to single-stranded (ss) DNA for helicase action. CMG must also …
Helicase activation and establishment of replication forks at chromosomal origins of replication
Many replication proteins assemble on the pre-RC-formed replication origins and constitute
the pre-initiation complex (pre-IC). This complex formation facilitates the conversion of Mcm2 …
the pre-initiation complex (pre-IC). This complex formation facilitates the conversion of Mcm2 …
Mechanism of eukaryotic origin unwinding is a dual helicase DNA shearing process
LD Langston, RE Georgescu… - Proceedings of the …, 2023 - National Acad Sciences
DNA replication in all cells begins with the melting of base pairs at the duplex origin to allow
access to single-stranded DNA templates which are replicated by DNA polymerases. In …
access to single-stranded DNA templates which are replicated by DNA polymerases. In …
Mcm10 regulates DNA replication elongation by stimulating the CMG replicative helicase
M Lõoke, MF Maloney, SP Bell - Genes & development, 2017 - genesdev.cshlp.org
Activation of the Mcm2–7 replicative DNA helicase is the committed step in eukaryotic DNA
replication initiation. Although Mcm2–7 activation requires binding of the helicase-activating …
replication initiation. Although Mcm2–7 activation requires binding of the helicase-activating …
Mechanisms for initiating cellular DNA replication
A Costa, IV Hood, JM Berger - Annual review of biochemistry, 2013 - annualreviews.org
The initiation of DNA replication represents a committing step to cell proliferation.
Appropriate replication onset depends on multiprotein complexes that help properly …
Appropriate replication onset depends on multiprotein complexes that help properly …