ETS proteins are a group of evolutionarily related, DNA-binding transcriptional factors.
These proteins direct gene expression in diverse normal and disease states by binding to …

A major goal of developmental biology is to understand the molecular mechanisms whereby
genetic signaling networks establish and maintain distinct cell types within multicellular …

Deciphering the mechanisms directing transcription factors (TFs) to specific genome regions
is essential to understand and predict transcriptional regulation. TFs recognize short DNA …

The formation of dynamic protein filaments contributes to various biological functions by
clustering individual molecules together and enhancing their binding to ligands. We report …

The ETS protein TEL, a transcriptional repressor, contains a PNT domain that, as an isolated
fragment in vitro, self-associates to form a head-to-tail polymer. How such polymerization …

DNA binding by the ETS transcriptional repressor ETV6 (or TEL) is auto-inhibited~ 50-fold
due to an α-helix that sterically blocks its ETS domain binding interface. Using NMR …

Among the diverse protein binding modules, Sam (Sterile alpha motif) domains attract
attention due to their versatility. They are present in different organisms and play many …

Proteins often act in complexes assembled via protein–protein interaction domains. The
sterile alpha motif (SAM) domain is one of the most prominent interaction domains in …

ETV6 (or TEL), a transcriptional repressor belonging to the ETS family, is frequently involved
in chromosomal translocations linked with human cancers. It displays a DNA-binding mode …

Mitochondria are membrane-bound organelles of endosymbiotic origin with limited protein-
coding capacity. The import of nuclear-encoded proteins and nucleic acids is required and …