For centuries, regular exercise has been acknowledged as a potent stimulus to promote,
maintain, and restore healthy functioning of nearly every physiological system of the human …

Skeletal muscle fibers are large syncytia but it is currently unknown whether gene
expression is coordinately regulated in their numerous nuclei. Here we show by snRNA-seq …

Skeletal muscle has an enormous plastic potential to adapt to various external and internal
perturbations. Although morphological changes in endurance-trained muscles are well …

Peripheral arterial disease (PAD) is a prevalent cardiovascular complication of limb vascular
insufficiency, causing ischemic injury, mitochondrial metabolic damage and functional …

The contractile properties of adult myofibers are shaped by their Myosin heavy chain isoform
content. Here, we identify by snATAC-seq a 42 kb super-enhancer at the locus regrouping …

Organogenesis is a highly complex and precisely regulated process. Here we profiled the
chromatin accessibility in> 350,000 cells derived from 13 mouse embryos at four …

Rapid gut-brain communication is critical to maintain energy balance and is disrupted in diet-
induced obesity. In particular, the role of carbohydrate overconsumption in the regulation of …

Skeletal muscle exhibits remarkable plasticity in response to environmental cues, with stress-
dependent effects on the fast-twitch and slow-twitch fibers. Although stress-induced gene …

Muscle cells have different phenotypes adapted to different usage, and can be grossly
divided into fast/glycolytic and slow/oxidative types. While most muscles contain a mixture of …

Skeletal muscle is a dynamic tissue the size of which can be remodeled through the
concerted actions of various cues. Here, we investigated the skeletal muscle transcriptional …