Histone acylations and chromatin dynamics: concepts, challenges, and links to metabolism

S Nitsch, L Zorro Shahidian, R Schneider - EMBO reports, 2021 - embopress.org
In eukaryotic cells, DNA is tightly packed with the help of histone proteins into chromatin.
Chromatin architecture can be modified by various post‐translational modifications of …

Metabolic decisions in development and disease—a Keystone Symposia report

J Cable, O Pourquié, KE Wellen… - Annals of the New …, 2021 - Wiley Online Library
There is an increasing appreciation for the role of metabolism in cell signaling and cell
decision making. Precise metabolic control is essential in development, as evident by the …

[HTML][HTML] Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells

B Lagerwaard, MD van der Hoek, J Hoeks… - Mechanisms of Ageing …, 2021 - Elsevier
Protein acylation via metabolic acyl-CoA intermediates provides a link between cellular
metabolism and protein functionality. A process in which acetyl-CoA and acetylation are fine …

Metabolic decisions in development and disease

L Mosteiro, H Hariri, J van den Ameele - Development, 2021 - journals.biologists.com
The intimate relationships between cell fate and metabolism have long been recognized, but
a mechanistic understanding of how metabolic pathways are dynamically regulated during …