Growing matter: a review of growth in living systems
E Kuhl - Journal of the Mechanical Behavior of Biomedical …, 2014 - Elsevier
Living systems can grow, develop, adapt, and evolve. These phenomena are non-intuitive to
traditional engineers and often difficult to understand. Yet, classical engineering tools can …
traditional engineers and often difficult to understand. Yet, classical engineering tools can …
[HTML][HTML] The living heart project: a robust and integrative simulator for human heart function
B Baillargeon, N Rebelo, DD Fox, RL Taylor… - European Journal of …, 2014 - Elsevier
The heart is not only our most vital, but also our most complex organ: Precisely controlled by
the interplay of electrical and mechanical fields, it consists of four chambers and four valves …
the interplay of electrical and mechanical fields, it consists of four chambers and four valves …
Multiscale simulations of left ventricular growth and remodeling
Cardiomyocytes can adapt their size, shape, and orientation in response to altered
biomechanical or biochemical stimuli. The process by which the heart undergoes structural …
biomechanical or biochemical stimuli. The process by which the heart undergoes structural …
Frontiers in growth and remodeling
A Menzel, E Kuhl - Mechanics research communications, 2012 - Elsevier
Unlike common engineering materials, living matter can autonomously respond to
environmental changes. Living structures can grow stronger, weaker, larger, or smaller …
environmental changes. Living structures can grow stronger, weaker, larger, or smaller …
Distribution of normal human left ventricular myofiber stress at end diastole and end systole: a target for in silico design of heart failure treatments
Ventricular wall stress is believed to be responsible for many physical mechanisms taking
place in the human heart, including ventricular remodeling, which is frequently associated …
place in the human heart, including ventricular remodeling, which is frequently associated …
Stretching skeletal muscle: chronic muscle lengthening through sarcomerogenesis
Skeletal muscle responds to passive overstretch through sarcomerogenesis, the creation
and serial deposition of new sarcomere units. Sarcomerogenesis is critical to muscle …
and serial deposition of new sarcomere units. Sarcomerogenesis is critical to muscle …
Heterogeneous growth-induced prestrain in the heart
Even when entirely unloaded, biological structures are not stress-free, as shown by YC
Fung׳ s seminal opening angle experiment on arteries and the left ventricle. As a result of …
Fung׳ s seminal opening angle experiment on arteries and the left ventricle. As a result of …
Propagation of uncertainty in the mechanical and biological response of growing tissues using multi-fidelity Gaussian process regression
A key feature of living tissues is their capacity to remodel and grow in response to
environmental cues. Within continuum mechanics, this process can be captured with the …
environmental cues. Within continuum mechanics, this process can be captured with the …
The impact of myocardial compressibility on organ-level simulations of the normal and infarcted heart
Myocardial infarction (MI) rapidly impairs cardiac contractile function and instigates
maladaptive remodeling leading to heart failure. Patient-specific models are a maturing …
maladaptive remodeling leading to heart failure. Patient-specific models are a maturing …
Computational models of cardiac hypertrophy
Cardiac hypertrophy, defined as an increase in mass of the heart, is a complex process
driven by simultaneous changes in hemodynamics, mechanical stimuli, and hormonal …
driven by simultaneous changes in hemodynamics, mechanical stimuli, and hormonal …