Heart failure (HF), the leading cause of death in the western world, develops when a cardiac
injury or insult impairs the ability of the heart to pump blood and maintain tissue perfusion. It …

It is useful to consider seven transmembrane receptors (7TMRs) as disordered proteins able
to allosterically respond to a number of binding partners. Considering 7TMRs as allosteric …

Practical relevance: Chronic kidney disease (CKD) is one of the most commonly diagnosed
diseases in older cats. In most cats, CKD is also a progressive disease and can be …

Childhood environment can have a profound impact on brain structure and function.
Epigenetic mechanisms have been shown to play a critical role in adaptive and maladaptive …

Nuclear receptors (NR) are a superfamily of ligand-activated transcription factors that
regulate development, reproduction, and metabolism of lipids, drugs and energy. The …

In the 60 years that have passed since the discovery of the mineralocorticoid hormone
aldosterone, much has been learned about its synthesis (both adrenal and extra-adrenal) …

Peptide hormones are small, processed, and secreted peptides that signal via membrane
receptors and play critical roles in normal and pathological physiology. The search for novel …

Practical relevance: Feline hypertension is a common disease in older cats that is frequently
diagnosed in association with other diseases such as chronic kidney disease and …

Obese individuals frequently develop hypertension, which is for an important part
attributable to renin-angiotensin-aldosterone system (RAAS) overactivity. This review …

Background and purpose: Inhibition of cholesteryl ester transfer protein (CETP) with
torcetrapib in humans increases plasma high density lipoprotein (HDL) cholesterol levels …