Protein kinase C, an elusive therapeutic target?
D Mochly-Rosen, K Das, KV Grimes - Nature reviews Drug discovery, 2012 - nature.com
Protein kinase C (PKC) has been a tantalizing target for drug discovery ever since it was first
identified as the receptor for the tumour promoter phorbol ester in 1982. Although initial …
identified as the receptor for the tumour promoter phorbol ester in 1982. Although initial …
Protein kinase C and other diacylglycerol effectors in cancer
EM Griner, MG Kazanietz - Nature Reviews Cancer, 2007 - nature.com
Almost three decades after the discovery of protein kinase C (PKC), we still have only a
partial understanding of how this family of serine/threonine kinases is involved in tumour …
partial understanding of how this family of serine/threonine kinases is involved in tumour …
mTOR signaling in tumorigenesis
Abstract mTOR (the mechanistic target of rapamycin) is an atypical serine/threonine kinase
involved in regulating major cellular functions including growth and proliferation …
involved in regulating major cellular functions including growth and proliferation …
Targeting protein kinase C for cancer therapy
S He, Q Li, Q Huang, J Cheng - Cancers, 2022 - mdpi.com
Simple Summary The protein kinase C (PKC) family belongs to serine-threonine kinases
and consists of several subtypes. Increasing evidence suggests that PKCs are critical …
and consists of several subtypes. Increasing evidence suggests that PKCs are critical …
Estrogen receptor β2 and β5 are associated with poor prognosis in prostate cancer, and promote cancer cell migration and invasion
Identification of molecular alterations in key proteins involved in breast cancer cell
proliferation and survival resulted in the development of a new treatment strategy with target …
proliferation and survival resulted in the development of a new treatment strategy with target …
Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state
CC Lin, KM Suen, PA Jeffrey, L Wieteska, JA Lidster… - Molecular cell, 2022 - cell.com
The recruitment of signaling proteins into activated receptor tyrosine kinases (RTKs) to
produce rapid, high-fidelity downstream response is exposed to the ambiguity of random …
produce rapid, high-fidelity downstream response is exposed to the ambiguity of random …
Exploitation of protein kinase C: a useful target for cancer therapy
AS Ali, S Ali, BF El-Rayes, PA Philip, FH Sarkar - Cancer treatment reviews, 2009 - Elsevier
Protein kinase C is a family of serine/threonine kinases. The PKC family is made up of at
least 12 isozymes, which have a role in cell proliferation, differentiation, angiogenesis, and …
least 12 isozymes, which have a role in cell proliferation, differentiation, angiogenesis, and …
Contribution of individual PKC isoforms to breast cancer progression
AJ Urtreger, MG Kazanietz, ED Bal de Kier Joffé - IUBMB life, 2012 - Wiley Online Library
The protein kinase C (PKC) family of serine/threonine kinases has been intensively studied
in cancer since their discovery as major receptors for the tumor‐promoting phorbol esters …
in cancer since their discovery as major receptors for the tumor‐promoting phorbol esters …
Alternative splicing in the NF-κB signaling pathway
JR Leeman, TD Gilmore - Gene, 2008 - Elsevier
Activation of transcription factor NF-κB can affect the expression of several hundred genes,
many of which are involved in inflammation and immunity. The proper NF-κB transcriptional …
many of which are involved in inflammation and immunity. The proper NF-κB transcriptional …
Wealth of opportunity-the C1 domain as a target for drug development
PM Blumberg, N Kedei, NE Lewin, D Yang… - Current drug …, 2008 - ingentaconnect.com
The diacylglycerol-responsive C1 domains of protein kinase C and of the related classes of
signaling proteins represent highly attractive targets for drug development. The signaling …
signaling proteins represent highly attractive targets for drug development. The signaling …