Modern trends in diuretics development
Diuretics are the first-line therapy for widespread cardiovascular and non-cardiovascular
diseases. Traditional diuretics are commonly prescribed for treatment in patients with …
diseases. Traditional diuretics are commonly prescribed for treatment in patients with …
Urea-aromatic interactions in biology
Noncovalent interactions are key determinants in both chemical and biological processes.
Among such processes, the hydrophobic interactions play an eminent role in folding of …
Among such processes, the hydrophobic interactions play an eminent role in folding of …
Structural characterization of human urea transporters UT-A and UT-B and their inhibition
G Chi, L Dietz, H Tang, M Snee, A Scacioc, D Wang… - Science …, 2023 - science.org
In this study, we present the structures of human urea transporters UT-A and UT-B to
characterize them at molecular level and to detail the mechanism of UT-B inhibition by its …
characterize them at molecular level and to detail the mechanism of UT-B inhibition by its …
Natural phenylethanoid glycosides diuretics derived from Lagopsis supina: biological activity, mechanism, molecular docking, and structure-activity relationship
L Yang, H Zeng, X Xia, H Wang, B Zhao, J He - Bioorganic Chemistry, 2022 - Elsevier
Aquaporins (AQPs) and vasopressin type 2 receptor (V2R) play a crucial role in urine
excretion and are widely used to explore novel diuretics. In this study, three …
excretion and are widely used to explore novel diuretics. In this study, three …
The chemical profiling of aqueous soluble fraction from Lagopsis supina and its diuretic effects via suppression of AQP and RAAS pathways in saline-loaded rats
L Yang, ZW He, JW He - Journal of Ethnopharmacology, 2021 - Elsevier
Abstract Ethnopharmacological relevance Lagopsis supina (Steph.) Ik.-Gal. ex Knorr. has
been widely used as a remedy treatment for diuresis and edema in China over 2500 years …
been widely used as a remedy treatment for diuresis and edema in China over 2500 years …
[HTML][HTML] Diuretic effect of Lagopsis supina fraction in saline-loaded rats is mediated through inhibition of aquaporin and renin-angiotensin-aldosterone systems and up …
J He, L Yang - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Abstract Lagopsis supina (Steph. ex Willd.) lk.-Gal. ex Knorr. has been used as a diuretic
agent in China for centuries with limited scientific evidence. This study investigated the …
agent in China for centuries with limited scientific evidence. This study investigated the …
[HTML][HTML] Discovery of novel diarylamides as orally active diuretics targeting urea transporters
S Zhang, Y Zhao, S Wang, M Li, Y Xu, J Ran… - … Pharmaceutica Sinica B, 2021 - Elsevier
Urea transporters (UT) play a vital role in the mechanism of urine concentration and are
recognized as novel targets for the development of salt-sparing diuretics. Thus, UT inhibitors …
recognized as novel targets for the development of salt-sparing diuretics. Thus, UT inhibitors …
N-(4-acetamidophenyl)-5-acetylfuran-2-carboxamide as a novel orally available diuretic that targets urea transporters with improved PD and PK properties
S Wang, Y Xu, Y Zhao, S Zhang, M Li, X Li, J He… - European Journal of …, 2021 - Elsevier
Urea transporters (UTs) have been identified as new targets for diuretics. Functional deletion
of UTs led to urea-selective urinary concentrating defects with relative salt sparing. In our …
of UTs led to urea-selective urinary concentrating defects with relative salt sparing. In our …
The urea transporter UT-A1 plays a predominant role in a urea-dependent urine-concentrating mechanism
X Geng, S Zhang, J He, A Ma, Y Li, M Li, H Zhou… - Journal of Biological …, 2020 - ASBMB
Urea transporters are a family of urea-selective channel proteins expressed in multiple
tissues that play an important role in the urine-concentrating mechanism of the mammalian …
tissues that play an important role in the urine-concentrating mechanism of the mammalian …
Urea transporters identified as novel diuretic drug targets
M Li, S Zhang, B Yang - Current Drug Targets, 2020 - ingentaconnect.com
Background: Urea Transporters are a family of membrane channel proteins that facilitate the
passive transport of urea across the plasma membrane. UTs are divided into two subgroups …
passive transport of urea across the plasma membrane. UTs are divided into two subgroups …