Microbial production of limonene and its derivatives: Achievements and perspectives

Y Ren, S Liu, G Jin, X Yang, YJ Zhou - Biotechnology Advances, 2020 - Elsevier
Limonene and its derivatives have great market potential with diverse applications in food,
pharmaceuticals, cosmetics, etc. Commercial production of limonene and its derivatives …

Towards efficient terpenoid biosynthesis: manipulating IPP and DMAPP supply

Q Wang, S Quan, H Xiao - Bioresources and Bioprocessing, 2019 - Springer
Terpenoids are a group of largest natural products with important biological functions, and
their efficient biosynthesis is of particular importance to both academia and industry. As the …

MEP pathway products allosterically promote monomerization of deoxy-D-xylulose-5-phosphate synthase to feedback-regulate their supply

X Di, D Ortega-Alarcon, R Kakumanu… - Plant …, 2023 - cell.com
Isoprenoids are a very large and diverse family of metabolites required by all living
organisms. All isoprenoids derive from the double-bond isomers isopentenyl diphosphate …

Development of isopentenyl phosphate kinases and their application in terpenoid biosynthesis

X Zhang, X Wang, Y Zhang, F Wang, C Zhang… - Biotechnology Advances, 2023 - Elsevier
As the largest class of natural products, terpenoids (> 90,000) have multiple biological
activities and a wide range of applications (eg, pharmaceutical, agricultural, personal care …

Regulation of plant vitamin metabolism: backbone of biofortification for the alleviation of hidden hunger

L Jiang, S Strobbe, D Van Der Straeten, C Zhang - Molecular plant, 2021 - cell.com
Micronutrient deficiencies include shortages of vitamins and minerals. They affect billions of
people and are associated with long-range effects on health, learning ability, and huge …

Engineering plant family TPS into cyanobacterial host for terpenoids production

A Rautela, S Kumar - Plant Cell Reports, 2022 - Springer
Terpenoids are synthesized naturally by plants as secondary metabolites, and are diverse
and complex in structure with multiple applications in bioenergy, food, cosmetics, and …

A systematic review of 1-Deoxy-D-xylulose-5-phosphate synthase in terpenoid biosynthesis in plants

S Tian, D Wang, L Yang, Z Zhang, Y Liu - Plant Growth Regulation, 2022 - Springer
Deoxy-D-xylulose-5-phosphate synthase (DXS) is the first rate-limiting enzyme involved in
the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway for terpenoids biosynthesis. Up to …

Positioning Bacillus subtilis as terpenoid cell factory

H Pramastya, Y Song, EY Elfahmi… - Journal of Applied …, 2021 - academic.oup.com
Increasing demands for bioactive compounds have motivated researchers to employ micro‐
organisms to produce complex natural products. Currently, Bacillus subtilis has been …

Pathway engineering, re-targeting, and synthetic scaffolding improve the production of squalene in plants

JD Bibik, SM Weraduwage, A Banerjee… - ACS Synthetic …, 2022 - ACS Publications
Plants are increasingly becoming an option for sustainable bioproduction of chemicals and
complex molecules like terpenoids. The triterpene squalene has a variety of …

Cell factories for methylerythritol phosphate pathway mediated terpenoid biosynthesis: An application of modern engineering towards sustainability

G Kant, A Pandey, A Hasan, F Bux, S Kumari… - Process …, 2024 - Elsevier
Terpenoids and their derivatives which are synthesized either through the methylerythritol
phosphate (MEP) or mevalonate (MVA) pathways represent a most diversified class of …