During fertilization, the egg and the sperm are supposed to contribute precisely one copy of
each chromosome to the embryo. However, human eggs frequently contain an incorrect …

It is well established that maternal age is associated with a rapid decline in the production of
healthy and high-quality oocytes resulting in reduced fertility in women older than 35 years …

Quiescence is a state of reversible proliferative arrest in which cells are not actively dividing
and yet retain the capacity to reenter the cell cycle upon receiving an appropriate stimulus …

Kinetochores are molecular machines that power chromosome segregation during the
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …

Chromosomal instability (CIN) is associated with many human diseases, including
neurodevelopmental or neurodegenerative conditions, age-related disorders and cancer …

Female fertility is inversely correlated with maternal age due to a depletion of the oocyte
pool and a reduction in oocyte developmental competence. Few studies have addressed the …

Accurate chromosome segregation during meiosis is crucial for reproduction. Human and
porcine oocytes transiently cluster their chromosomes before the onset of spindle assembly …

The gain or loss of a chromosome—or aneuploidy—acts as one of the major triggers for
infertility and pregnancy loss in humans. These chromosomal abnormalities affect more than …

Pregnancy is established during the periconceptional period as a continuum beginning with
blastocyst attachment to the endometrial epithelial surface followed by embryo invasion and …

The female reproductive system is of great significance to women's health. Aging of the
female reproductive system occurs approximately 10 years prior to the natural age …