Functional roles of enzyme dynamics in accelerating active site chemistry: Emerging techniques and changing concepts

S Gao, JP Klinman - Current opinion in structural biology, 2022 - Elsevier
With the growing acceptance of the contribution of protein conformational ensembles to
enzyme catalysis and regulation, research in the field of protein dynamics has shifted toward …

Dynamical activation of function in metalloenzymes

JP Klinman - FEBS letters, 2023 - Wiley Online Library
Formulations of hydrogen tunneling in enzyme‐catalysed C–H activation reactions indicate
enthalpic barriers to reaction that are independent of chemical steps and dependent on the …

[HTML][HTML] 13C ENDOR Spectroscopy-Guided MD Computations Reveals the Structure of the Enzyme-Substrate Complex of an Active, N-linked Glycosylated …

A Sharma, C Whittington, M Jabed, SG Hill… - Biochemistry, 2023 - ncbi.nlm.nih.gov
Lipoxygenase (LOX) enzymes produce important cell-signaling mediators yet attempts to
capture and characterize LOX-substrate complexes by X-ray co-crystallography are …

Temperature-dependent hydrogen deuterium exchange shows impact of analog binding on adenosine deaminase flexibility but not embedded thermal networks

S Gao, W Zhang, SL Barrow, AT Iavarone… - Journal of Biological …, 2022 - ASBMB
The analysis of hydrogen deuterium exchange by mass spectrometry as a function of
temperature and mutation has emerged as a generic and efficient tool for the spatial …