Human immunodeficiency virus type 1 (HIV-1), a lentivirus that causes acquired
immunodeficiency syndrome (AIDS), poses a serious threat to global public health. Since …

Abstract HIV-1 integrase (IN) enzyme, one of the three main enzymes of HIV-1, catalyzed the
insertion of the viral DNA into the genome of host cells. Because of the lack of its homologue …

After restricting the proliferation of CD4+ T cells, Human Immunodeficiency Virus (HIV),
infection persists at a very fast rate causing Acquired Immunodeficiency Syndrome (AIDS) …

A new series of quinolone-3-carboxylic acids featuring different hydrophobic groups at N-1,
C-2, C-7, and C-8 positions were synthesized and evaluated for their activity against single …

Background: The emergence of drug-resistant viral strains has created the need for the
development of novel anti-HIV agents with a diverse structure that targets key enzymes in …

Design, Synthesis, Molecular Modeling, In Silico ADME Studies and Anti-HIV-1 Assay of New
Diazocoumarin Derivatives - PMC Back to Top Skip to main content NIH NLM Logo Access keys …

A series of 2-benzoxazolinone, diazocoumarin and quinazoline derivatives have been
shown to inhibit HIV replication in cell culture. To understand the pharmacophore properties …

An efficient method for visible-light-induced perfluoroalkylaion of quinolin-4-ol has been
reported. In the presence of t-BuONa and perfluoroalkyl iodide, quinolin-4-ol underwent …

Background: Although major efforts have been devoted to the effective treatment of HIV-1
infection, it has remained one of the leading causes of deaths around the world. So …

Novel quinolone derivatives featuring an 1, 3, 4-oxadiazole ring as a metal-chelating
component and a benzyl group base on HIV-1 integrase inhibitors pharmacophore were …