Systemic inflammation after stroke: implications for post‐stroke comorbidities

A Simats, A Liesz - EMBO molecular medicine, 2022 - embopress.org
Immunological mechanisms have come into the focus of current translational stroke
research, and the modulation of neuroinflammatory pathways has been identified as a …

Immune interventions in stroke

Y Fu, Q Liu, J Anrather, FD Shi - Nature Reviews Neurology, 2015 - nature.com
Approaches for the effective management of acute stroke are sparse, and many measures
for brain protection fail. However, our ability to modulate the immune system and modify the …

Microbiota dysbiosis controls the neuroinflammatory response after stroke

V Singh, S Roth, G Llovera, R Sadler… - Journal of …, 2016 - Soc Neuroscience
Acute brain ischemia induces a local neuroinflammatory reaction and alters peripheral
immune homeostasis at the same time. Recent evidence has suggested a key role of the gut …

DAMP signaling is a key pathway inducing immune modulation after brain injury

A Liesz, A Dalpke, E Mracsko, S Roth… - Journal of …, 2015 - Soc Neuroscience
Acute brain lesions induce profound alterations of the peripheral immune response
comprising the opposing phenomena of early immune activation and subsequent …

Systemic inflammation in hemorrhagic strokes–A novel neurological sign and therapeutic target?

AR Saand, F Yu, J Chen… - Journal of Cerebral Blood …, 2019 - journals.sagepub.com
Growing evidences suggest that stroke is a systemic disease affecting many organ systems
beyond the brain. Stroke-related systemic inflammatory response and immune …

Ischemia, immunosuppression and infection—tackling the predicaments of post-stroke complications

R Shim, CHY Wong - International journal of molecular sciences, 2016 - mdpi.com
The incidence of stroke has risen over the past decade and will continue to be one of the
leading causes of death and disability worldwide. While a large portion of immediate death …

Trauma-induced damage-associated molecular patterns-mediated remote organ injury and immunosuppression in the acutely ill patient

M Vourc'h, A Roquilly, K Asehnoune - Frontiers in immunology, 2018 - frontiersin.org
Trauma is one of the leading causes of death and disability in the world. Multiple trauma or
isolated traumatic brain injury are both indicative of human tissue damage. In the early …

Stroke-induced immunosuppression and poststroke infection

K Shi, K Wood, FD Shi, X Wang, Q Liu - Stroke and vascular neurology, 2018 - svn.bmj.com
Infections occur commonly after stroke and are strongly associated with an unfavourable
functional outcome of these patients. Approaches for effective management of poststroke …

Neuroinflammation and peripheral immunity: Focus on ischemic stroke

H Wang, S Zhang, L Xie, Z Zhong, F Yan - International …, 2023 - Elsevier
Ischemic stroke (IS) produces a powerful inflammatory cascade in the brain, resulting in the
occurrence of neuroinflammation. Neuroinflammation is triggered not only by resident …

Neuroprotective treatments for ischemic stroke: opportunities for nanotechnology

J Kong, R Chu, Y Wang - Advanced Functional Materials, 2022 - Wiley Online Library
Stroke is one of the major causes of death and severe disability worldwide. At present,
intravenous thrombolysis to restore blood flow at the ischemic part of the brain is the main …