Integrins are cell adhesion receptors that are evolutionary old and that play important roles
during developmental and pathological processes. The integrin family is composed of 24 αβ …

The integrin family of cell adhesion receptors plays a major role in mediating interactions
between cells and the extracellular matrix. Normal adult articular chondrocytes express …

Hypertrophic differentiation is not only the terminal process of endochondral ossification in
the growth plate but is also an important pathological change in osteoarthritic cartilage …

Chondrocytes and osteoblasts are two primary cell types in the skeletal system that are
differentiated from common mesenchymal progenitors. It is believed that osteoblast …

Cartilage extracellular matrix (ECM) is composed primarily of the network type II collagen
(COLII) and an interlocking mesh of fibrous proteins and proteoglycans (PGs), hyaluronic …

Integrins are adhesion receptors that allow cells to sense and respond to
microenvironmental signals encoded by the extracellular matrix. They are crucial for the …

Cell division, the purpose of which is to enable cell replication, and in particular to distribute
complete, accurate copies of genetic material to daughter cells, is essential for the …

The ternary complex of integrin-linked kinase (ILK), PINCH and parvin functions as a
signalling platform for integrins by interfacing with the actin cytoskeleton and many diverse …

Osteoarthritis is characterized by a progressive degradation of articular cartilage leading to
loss of joint function. The molecular mechanisms regulating pathogenesis and progression …

The network of actin filaments is one of the crucial cytoskeletal structures contributing to the
morphological framework of a cell and which participates in the dynamic regulation of …