Enzymes play key roles in fungal pathogenesis. Manipulation of enzyme expression or
activity can significantly alter the infection process, and enzyme expression profiles can be a …

The ability of countless representatives of the Kingdom Fungi to adapt to and proliferate in
diverse environments is facilitated by regulation of their secretomes to respond to changes …

In recent decades, Galleria mellonella (Lepidoptera: Pyralidae) have emerged as a model
system to explore experimental aspects of fungal pathogenesis. The benefits of the G …

Metabolically quiescent pathogens can persist in a viable non-replicating state for months or
even years. For certain infectious diseases, such as tuberculosis, cryptococcosis …

Phosphatases, together with kinases and transcription factors, are key components in
cellular signalling networks. Here, we present a systematic functional analysis of the …

Phosphate is an essential macronutrient required for cell growth and division. Pho84 is the
major high-affinity cell-surface phosphate importer of Saccharomyces cerevisiae and a …

The ability of pathogenic fungi to acquire essential macro and micronutrients during infection
is a well-established virulence trait. Recent studies in the major human fungal pathogens …

The opportunistic fungal pathogen Cryptococcus neoformans causes life-threatening
meningitis in immunocompromised individuals. The expression of virulence factors …

Cryptococcus neoformans is an opportunistic fungal pathogen and a leading cause of fungal-
infection-related fatalities, especially in immunocompromised hosts. Several virulence …

In the human-pathogenic fungus Cryptococcus neoformans, the inositol polyphosphate
signaling pathway is critical for virulence. We recently demonstrated the key role of the …