Engineering Synthetic Erythrocytes as Next‐Generation Blood Substitutes

FL Gomes, SH Jeong, SR Shin, J Leijten… - Advanced Functional …, 2024 - Wiley Online Library
Blood scarcity is one of the main causes of healthcare disruptions worldwide, with blood
shortages occurring at an alarming rate. Over the last decades, blood substitutes have …

Innovative Nanocomposite Scaffolds Containing ZIF-8 Nanoparticles for Improving Wound Healing: A Review

P Nezhad-Mokhtari, R Rahbarghazi… - Journal of Polymers and …, 2024 - Springer
Multifunctional nanocomposite scaffolds, particularly those incorporating zeolitic imidazolate
framework-8 nanoparticles (ZIF-8 NPs), are emerging as effective solutions for skin and …

[HTML][HTML] A novel PEG-mediated approach to entrap hemoglobin (Hb) within ZIF-8 nanoparticles: Balancing crystalline structure, Hb content and functionality

C Coll-Satue, M Rubio-Huertas, A Ducrot… - Biomaterials …, 2024 - Elsevier
Hemoglobin (Hb)-based oxygen carriers are investigated as a potential alternative or
supplement to regular blood transfusions, particularly in critical and life-threatening …

In vitro and in vivo investigations of hemoglobin-loaded PEGylated ZIF-8 nanoparticles as oxygen carriers for emergency transfusion

G Bor, W Jin, D Douka, NJ Borthwick, X Liu… - Biomaterials …, 2025 - Elsevier
The limitations of traditional blood supply systems, particularly where ideal storage is
unfeasible, challenge the efficacy of transfusion medicine, especially in emergencies and …

Oxygen Gas-Filled Metal-Organic Frameworks (MOFs) Delivery System: A Hypothetical Design for Injectable Oxygen

C Singh, CB Jha, S Upadhyayula, R Mathur - Medical Hypotheses, 2024 - Elsevier
Oxygen delivery systems are crucial in critical care medicine, particularly for managing acute
respiratory distress. This study presents a novel approach, exploring the potential of Metal …

Synthesis of bioactive hemoglobin-based oxygen carrier nanoparticles via metal-phenolic complexation

M Nadimifar, W Jin, C Coll-Satue, G Bor… - Biomaterials …, 2024 - Elsevier
The transfusion of donor red blood cells (RBCs) is seriously hampered by important
drawbacks that include limited availability and portability, the requirement of being stored in …

Optimization and Investigation of Hemoglobin‐Loaded ZIF‐90 Metal–Organic Framework Nanoparticles as Artificial Oxygen Carriers

D Douka, W Jin, C Cantallops‐Iglesias… - Particle & Particle …, 2024 - Wiley Online Library
Blood transfusions are vital, yet limited shelf‐life and storage conditions of red blood cells
(RBCs) hinder their use in emergencies. Hemoglobin‐based oxygen carriers (HBOCs) aim …

Hemoglobin-stabilized gold nanoclusters displaying oxygen transport ability, self-antioxidation, auto-fluorescence properties and long-term storage potential

X Cun, MMT Jansman, X Liu, V Boureau… - RSC …, 2023 - pubs.rsc.org
The development of hemoglobin (Hb)-based oxygen carriers (HBOCs) holds a lot of
potential to overcome important drawbacks of donor blood such as a short shelf life or the …

Therapeutic delivery of oxygen using artificial oxygen carriers demonstrates the possibility of treating a wide range of diseases

N Mohanto, H Mondal, YJ Park, JP Jee - Journal of Nanobiotechnology, 2025 - Springer
Artificial oxygen carriers have emerged as potential substitutes for red blood cells in
situations of major blood loss, including accidents, surgical procedures, trauma, childbirth …

[HTML][HTML] Nitric oxide-triggering activity of gold-, platinum-and cerium oxide-nanozymes from S-nitrosothiols and diazeniumdiolates

MMT Jansman, E Norkute, W Jin, PJ Kempen… - Colloids and Surfaces B …, 2024 - Elsevier
Cardiovascular diseases pose a significant global health challenge, contributing to high
mortality rates and impacting overall well-being and quality of life. Nitric oxide (NO) plays a …