Targeted therapy of cancer with radiolabeled antibodies

DM Goldenberg - Journal of Nuclear Medicine, 2002 - Soc Nuclear Med
This review focuses on the use of radiolabeled antibodies in the therapy of cancer, termed
radioimmunotherapy (RAIT). Basic problems concerning the choice of antibody and …

A comprehensive overview of radioguided surgery using gamma detection probe technology

SP Povoski, RL Neff, CM Mojzisik, DM O'Malley… - World journal of surgical …, 2009 - Springer
The concept of radioguided surgery, which was first developed some 60 years ago, involves
the use of a radiation detection probe system for the intraoperative detection of …

[图书][B] Cancer biology

RW Ruddon - 2007 - books.google.com
The fourth edition of this classic text provides a thorough, yet concise review of the cellular
and molecular mechanisms involved in the transformation of normal into malignant cells, the …

Synthesis of 1-(p-isothiocyanatobenzyl) derivatives of DTPA and EDTA. Antibody labeling and tumor-imaging studies

MW Brechbiel, OA Gansow, RW Atcher… - Inorganic …, 1986 - ACS Publications
To investigate the nlIn labeling of tumor-localizing monoclonal antibodies (MoAb), we have
synthesized the chelate l-(p-iso-thiocyanatobenzyl) diethylenetriaminepentaacetic acid (p …

Three-step monoclonal antibody tumor targeting in carcinoembryonic antigen-positive patients

G Paganelli, P Magnani, F Zito, E Villa, F Sudati… - Cancer research, 1991 - AACR
We described a method to postlabel, in vivo, biotinylated monoclonal antibodies pretargeted
onto tumor deposits when most of the non-tumorbound antibodies have already been …

Immuno-PET of colorectal cancer with a CEA-targeted [68 Ga] Ga-nanobody: From bench to bedside

L Li, X Lin, L Wang, X Ma, Z Zeng, F Liu, B Jia… - European Journal of …, 2023 - Springer
Purpose An accurate diagnosis of colorectal carcinoma (CRC) can assist physicians in
developing reasonable therapeutic regimens, thereby significantly improving the patient's …

An analysis of monoclonal antibody distribution in microscopic tumor nodules: consequences of a “binding site barrier”

W van Osdol, K Fujimori, JN Weinstein - Cancer research, 1991 - AACR
Rational in vivo application of monoclonal antibodies for diagnosis and therapy of cancer
requires an understanding of both the global and microscopic pharmacology of …

In Vivo Quantification of Tumor Receptor Binding Potential with Dual-Reporter Molecular Imaging

KM Tichauer, KS Samkoe, KJ Sexton… - Molecular Imaging and …, 2012 - Springer
Purpose Receptor availability represents a key component of current cancer management.
However, no approaches have been adopted to do this clinically, and the current standard of …

Use of radiolabelled monoclonal anti-CEA antibodies for the detection of human carcinomas by external photoscanning and tomoscintigraphy

JP Mach, F Buchegger, M Forni, J Ritschard, C Berche… - Immunology today, 1981 - cell.com
Paul Ehrlich's inspired concept of'magic bullets' for the cure (~ f diseases has beer~
revitalized by recent advances in immunology j. In parlicular, the development of ceil fusion …

Overview of transition metal and lanthanide complexes as diagnostic tools

L Thunus, R Lejeune - Coordination chemistry reviews, 1999 - Elsevier
This review presents an overview of various elements used in the preparation of imaging
contrast agents. After a brief introduction to the history of the development of labelling …