Neurodegenerative diseases are disabling and fatal neurological disorders that currently
lack effective treatment. Neural stem cell (NSC) transplantation has been studied as a …

In Parkinson's disease (PD), there are currently no effective therapies to prevent or slow
down disease progression. Cell replacement therapy using human pluripotent stem cell …

Human pluripotent stem cells show considerable promise for applications in regenerative
medicine, including the development of cell replacement paradigms for the treatment of …

Midbrain dopamine (mDA) neurons can be replaced in patients with Parkinson's disease
(PD) in order to provide long-term improvement in motor functions. The limited capacity for …

Stem cell therapies for Parkinson's disease are at an exciting time of development, and
several clinical trials have recently been initiated. Human pluripotent stem cells are …

The etiology of many neurological diseases affecting the central nervous system (CNS) is
unknown and still needs more effective and specific therapeutic approaches. Gene therapy …

Neurotrophic factors (NTFs) are small secreted proteins that support the development,
maturation and survival of neurons. NTFs injected into the brain rescue and regenerate …

The directed differentiation of human pluripotent stem cells (hPSCs) into defined populations
has advanced regenerative medicine, especially for Parkinson's disease where clinical trials …

Neurodegenerative diseases are characterized by irreversible cell damage, loss of neuronal
cells and limited regeneration potential of the adult nervous system. Pluripotent stem cells …

Cell-based therapies hold great promise for brain repair after stroke. While accumulating
evidence confirms the preclinical and clinical benefits of cell therapies, the underlying …