Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …

The mammalian CNS is an intricate and fragile structure, which on one hand is open to
change in order to store information, but on the other hand is vulnerable to damage from …

Inflammation is a protective reaction activated in response to detrimental stimuli, such as
dead cells, irritants or pathogens, by the evolutionarily conserved immune system and is …

The prevalence of neurodegenerative disease has increased significantly in recent years,
and with a rapidly aging global population, this trend is expected to continue. These …

The extracellular forms of the IL‐1 cytokines are active through binding to specific receptors
on the surface of target cells. IL‐1 ligands bind to the extracellular portion of their ligand …

The role of the cytokines and receptors of the IL-1 family in inflammation is well known.
Several cytokines of the family have a powerful inflammatory activity, with IL-1β being the …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease in
which many processes are detected including (neuro) inflammation. Many drugs have been …

Neurodegenerative diseases are chronic, progressive disorders that occur in the central
nervous system (CNS). They are characterized by the loss of neuronal structure and function …

Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of motoneurons in
the cerebral cortex, brainstem and spinal cord. Neuroinflammation plays an important role in …

Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of motor neurons in
the motor cortex, brainstem, and spinal cord. Although ALS is considered a motor neuron …