Recent advancements of coumarin-based anticancer agents: An up-to-date review
Heading the list of the critical health-related issues worldwide, cancer continues to be a one
of the most serious life-threatening diseases. The rate of cancer-related mortality is at …
of the most serious life-threatening diseases. The rate of cancer-related mortality is at …
Coumarin-containing hybrids and their anticancer activities
L Zhang, Z Xu - European Journal of Medicinal Chemistry, 2019 - Elsevier
Cancer is the second leading cause of death worldwide, and it results in around 9 million
deaths annually. The anticancer agents play an intriguing role in the treatment of cancers …
deaths annually. The anticancer agents play an intriguing role in the treatment of cancers …
Latest developments in coumarin-based anticancer agents: mechanism of action and structure–activity relationship studies
Many researchers around the world are working on the development of novel anticancer
drugs with different mechanisms of action. In this case, coumarin is a highly promising …
drugs with different mechanisms of action. In this case, coumarin is a highly promising …
Sulfonamide derivatives as multi-target agents for complex diseases
Sulfonamide derivatives are frequently seen structural motifs in medicinal chemistry. Almost
a century after Gerhard Domagk's pioneering work leading to the first sulfonamide antibiotic …
a century after Gerhard Domagk's pioneering work leading to the first sulfonamide antibiotic …
New quinoxaline-based VEGFR-2 inhibitors: Design, synthesis, and antiproliferative evaluation with in silico docking, ADMET, toxicity, and DFT studies
A new series of 3-methylquinoxaline-based derivatives having the same essential
pharmacophoric features as VEGFR-2 inhibitors have been synthesized and evaluated for …
pharmacophoric features as VEGFR-2 inhibitors have been synthesized and evaluated for …
Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma: In Silico, In Vitro, and SAR …
C Ma, MS Taghour, A Belal, ABM Mehany… - Frontiers in …, 2021 - frontiersin.org
Guided by the structural optimization principle and the promising anticancer effect of the
quinoxaline nucleus, a new series of novel HDAC inhibitors were designed and …
quinoxaline nucleus, a new series of novel HDAC inhibitors were designed and …
New quinoxaline derivatives as VEGFR-2 inhibitors with anticancer and apoptotic activity: Design, molecular modeling, and synthesis
Abstract New series of [1, 2, 4] triazolo [4, 3-a] quinoxalin-4 (5H)-one and [1, 2, 4] triazolo [4,
3-a] quinoxaline derivatives have been designed, synthesized, and biologically assessed for …
3-a] quinoxaline derivatives have been designed, synthesized, and biologically assessed for …
New bis ([1, 2, 4] triazolo)[4, 3-a: 3′, 4′-c] quinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers: Design, synthesis, in silico studies, and anticancer …
A new series of bis ([1, 2, 4] triazolo)[4, 3-a: 3′, 4′-c] quinoxaline derivatives were
designed and synthesized to have the main essential pharmacophoric features of VEGFR-2 …
designed and synthesized to have the main essential pharmacophoric features of VEGFR-2 …
Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic …
S El-Kalyoubi, MM Khalifa, MT Abo-Elfadl… - Journal of enzyme …, 2023 - Taylor & Francis
A new wave of dual Topo I/II inhibitors was designed and synthesised via the hybridisation
of spirooxindoles and pyrimidines. In situ selenium nanoparticles (SeNPs) for some …
of spirooxindoles and pyrimidines. In situ selenium nanoparticles (SeNPs) for some …
Design, molecular docking, in vitro, and in vivo studies of new quinazolin-4 (3H)-ones as VEGFR-2 inhibitors with potential activity against hepatocellular carcinoma
A series of new VEGFR-2 inhibitors were designed, synthesized and evaluated for their anti-
proliferative activities against hepatocellular carcinoma (HepG-2 cell line). Compound 29 b …
proliferative activities against hepatocellular carcinoma (HepG-2 cell line). Compound 29 b …