Glia of the human retina

A Reichenbach, A Bringmann - Glia, 2020 - Wiley Online Library
The human retina contains three types of glial cells: microglia and two types of macroglia,
astrocytes and Müller cells. Macroglia provide homeostatic and metabolic support to …

The role of microglia in diabetic retinopathy: inflammation, microvasculature defects and neurodegeneration

C Altmann, MHH Schmidt - International journal of molecular sciences, 2018 - mdpi.com
Diabetic retinopathy is a common complication of diabetes mellitus, which appears in one
third of all diabetic patients and is a prominent cause of vision loss. First discovered as a …

Microglia in the retina: roles in development, maturity, and disease

SM Silverman, WT Wong - Annual review of vision science, 2018 - annualreviews.org
Microglia, the primary resident immune cell type, constitute a key population of glia in the
retina. Recent evidence indicates that microglia play significant functional roles in the retina …

Retinal microglia: just bystander or target for therapy?

M Karlstetter, R Scholz, M Rutar, WT Wong… - Progress in retinal and …, 2015 - Elsevier
Resident microglial cells can be regarded as the immunological watchdogs of the brain and
the retina. They are active sensors of their neuronal microenvironment and rapidly respond …

Activation of retinal glial cells contributes to the degeneration of ganglion cells in experimental glaucoma

Y Miao, GL Zhao, S Cheng, Z Wang, XL Yang - Progress in retinal and eye …, 2023 - Elsevier
Elevation of intraocular pressure (IOP) is a major risk factor for neurodegeneration in
glaucoma. Glial cells, which play an important role in normal functioning of retinal neurons …

Retina in a dish: Cell cultures, retinal explants and animal models for common diseases of the retina

S Schnichels, F Paquet-Durand, M Löscher… - Progress in retinal and …, 2021 - Elsevier
For many retinal diseases, including age-related macular degeneration (AMD), glaucoma,
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …

Retinal microglia–A key player in healthy and diseased retina

G Rathnasamy, WS Foulds, EA Ling, C Kaur - Progress in neurobiology, 2019 - Elsevier
Microglia, the resident immune cells of the brain and retina, are constantly engaged in the
surveillance of their surrounding neural tissue. During embryonic development they infiltrate …

Droplet-based method and apparatus for composite single-cell nucleic acid analysis

A Regev, EZ Macosko, SA McCarroll… - US Patent …, 2023 - Google Patents
US11597964B2 - Droplet-based method and apparatus for composite single-cell nucleic acid
analysis - Google Patents US11597964B2 - Droplet-based method and apparatus for composite …

Neural remodeling in retinal degeneration

RE Marc, BW Jones, CB Watt, E Strettoi - Progress in retinal and eye …, 2003 - Elsevier
Mammalian retinal degenerations initiated by gene defects in rods, cones or the retinal
pigmented epithelium (RPE) often trigger loss of the sensory retina, effectively leaving the …

Contribution of microglia‐mediated neuroinflammation to retinal degenerative diseases

MH Madeira, R Boia, PF Santos… - Mediators of …, 2015 - Wiley Online Library
Retinal degenerative diseases are major causes of vision loss and blindness worldwide and
are characterized by chronic and progressive neuronal loss. One common feature of retinal …