Swine disease models are essential for mimicry of human metabolic and vascular
pathophysiology, thereby enabling high-fidelity translation to human medicine. The …

This review aims to describe and compare porcine models of metabolic syndrome. This
syndrome and its associated secondary comorbidities are set to become the greatest …

Background Animal models that mimic diet-induced human pathogenesis of chronic
diseases are of increasing importance in preclinical studies. The Ossabaw pig is an …

The heterogeneity and complexity of coronary vasculature (structure) and myocardial flow
(function) have fractal-like characteristics and can be described by scaling laws with …

Atherosclerosis is a chronic inflammatory disorder that is the underlying cause of most
cardiovascular disease. Resident cells of the artery wall and cells of the immune system …

Background Chronic coronary retroperfusion to treat myocardial ischemia has previously
failed due to edema and hemorrhage of coronary veins suddenly exposed to arterial …

Cardiac allograft vasculopathy (CAV) is one of the most common long-term complications in
patients following heart transplantation. Because of its irreversible nature, early detection is …

Over the last 50 years, a vast amount of knowledge pertaining to the structure and control
mechanisms that govern function of the coronary circulation has been obtained through …

Ischemic heart disease due to macrovascular atherosclerosis and microvascular dysfunction
is the major cause of death worldwide and the unabated increase in metabolic syndrome is …

Background Coronary artery disease (CAD) results from the buildup of cholesterol,
inflammatory factors, and proliferating smooth muscle cells within a vessel wall. This plaque …