Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …

Cancer cells are characterized by a metabolic shift in cellular energy production,
orchestrated by the transcription factor HIF-1α, from mitochondrial oxidative phosphorylation …

Cancer cell metabolism leads to a uniquely acidic microenvironment in solid tumors, but
exploiting the labile extracellular pH differences between cancer and normal tissues for …

Contrast-enhanced magnetic resonance imaging (MRI) is an indispensable tool for
diagnostic medicine. However, safety concerns related to gadolinium in commercial MRI …

The vast majority of cancers exhibit increased glucose uptake and glycolysis regardless of
oxygen availability. This metabolic shift leads to an enhanced production of lactic acid that …

Chemical exchange saturation transfer (CEST) is a novel contrast mechanism for magnetic
resonance imaging (MRI). CEST MRI selectively saturates exchangeable protons that are …

The purpose of this work is to provide an exhaustive overview of the emerging biosensor
technologies for the detection of analytes of interest for food, environment, security, and …

Natural pH regulatory mechanisms can be overruled during several pathologies such as
cancer, inflammation and ischaemia, leading to local pH changes in the human body. Here …

Initial studies of cancer metabolism in the early 1920s found that cancer cells were
phenotypically characterized by aerobic glycolysis, in that these cells favor glucose uptake …

For topical treatment of skin cancer, the design of pH-responsive nanocarriers able to
selectively release the drug in the tumor acidic microenvironment represents a reliable …