A review of HPRT and its emerging role in cancer

MH Townsend, RA Robison, KL O'Neill - Medical Oncology, 2018 - Springer
Hypoxanthine guanine phosphoribosyltransferase (HPRT) is a common salvage
housekeeping gene with a historically important role in cancer as a mutational biomarker. As …

Thymidine kinase: diagnostic and prognostic potential

KL O'Neill, MR Buckwalter… - Expert review of molecular …, 2001 - Taylor & Francis
Thymidine kinase is a cell cycle-dependent marker that can be detected in the serum of
patients diagnosed with many different types of cancer. Serum levels of thymidine kinase …

Production and characterisation of a novel chicken IgY antibody raised against C-terminal peptide from human thymidine kinase 1

C Wu, R Yang, J Zhou, S Bao, L Zou, P Zhang… - Journal of …, 2003 - Elsevier
Egg yolk is a good source of highly specific antibodies against mammalian antigens
because of the phylogenetic distance between birds and mammals. Chicken egg yolk …

Concentration of thymidine kinase 1 in serum (S-TK1) is a more sensitive proliferation marker in human solid tumors than its activity

Q He, P Zhang, L Zou, H Li, X Wang… - Oncology …, 2005 - spandidos-publications.com
Activity of thymidine kinase 1 in serum (STK) is a useful marker for leukaemia and
lymphoma, but not for solid tumors. We investigate thymidine kinase 1 concentration in …

Serum thymidine kinase 1 is a prognostic and monitoring factor in patients with non-small cell lung cancer

HX Li, DS Lei, XQ Wang, S Skog… - Oncology …, 2005 - spandidos-publications.com
Abstract Thymidine kinase 1 (TK1) is a pyrimidine metabolic pathway enzyme involved in
salvage DNA synthesis and thus, a cell cycle-dependent marker. We have developed anti …

Breast and prostate cancer patients differ significantly in their serum Thymidine kinase 1 (TK1) specific activities compared with those hematological malignancies and …

KK Jagarlamudi, LO Hansson, S Eriksson - BMC cancer, 2015 - Springer
Abstract Background Thymidine kinase 1 (TK1) is a cellular enzyme involved in DNA
precursor synthesis, and its activity has been used as a proliferation marker for monitoring …

H19, a long non-coding RNA, mediates transcription factors and target genes through interference of microRNAs in pan-cancer

A Li, S Mallik, H Luo, P Jia, DF Lee, Z Zhao - Molecular Therapy-Nucleic …, 2020 - cell.com
Long non-coding RNAs (lncRNAs) have recently been found to be important in gene
regulation. lncRNA H19 has been reported to play an oncogenic role in many human …

Membrane expression of thymidine kinase 1 and potential clinical relevance in lung, breast, and colorectal malignancies

EG Weagel, W Burrup, R Kovtun, EJ Velazquez… - Cancer Cell …, 2018 - Springer
Background Lung, breast, and colorectal malignancies are the leading cause of cancer-
related deaths in the world causing over 2.8 million cancer-related deaths yearly. Despite …

Serum thymidine kinase 1 concentration as a prognostic factor of chemotherapy-treated non-Hodgkin's lymphoma patients

ZL Pan, XY Ji, YM Shi, J Zhou, E He, S Skog - Journal of cancer research …, 2010 - Springer
Purpose This study was performed to examine possible use of thymidine kinase 1
concentration in serum (STK1) for prognosis of non-Hodgkin's lymphoma patients following …

Sensitive nonradiometric method for determining thymidine kinase 1 activity

A Ohrvik, M Lindh, R Einarsson, J Grassi… - Clinical …, 2004 - academic.oup.com
Abstract Background: Thymidine kinase 1 (TK1) is a cytoplasmic enzyme, produced only in
the S-phase of proliferating cells, that has potential as a tumor marker. Specific …