Computational modelling of the lungs is an active field of study that integrates computational
advances with lung biophysics, biomechanics, physiology and medical imaging to promote …

Aging is a slow process that affects all organs, and the lung is no exception. At the alveolar
level, aging increases airspace size with thicker and stiffer septal walls, and straighter and …

The relationship between pressure (P) and volume (V) in the human lung has been
extensively studied. However, the combined effects of gravity and the mechanical properties …

Collagen fibers, one of the key load-bearing components of the extracellular matrix,
contribute significantly to tissue integrity through their mechanical properties of strain …

Patients with acute exacerbation of lung fibrosis with usual interstitial pneumonia (EUIP)
pattern are at increased risk for ventilator-induced lung injury (VILI) and mortality when …

Early lung cancer lesions develop within a unique microenvironment that undergoes
constant cyclic stretch from respiration. While tumor stiffening is an established driver of …

Emphysema is a progressive disease characterized by irreversible tissue destruction and
airspace enlargement, which manifest as low attenuation area (LAA) on CT images …

Idiopathic pulmonary fibrosis (IPF) is a devastating, progressive and ultimately fatal
interstitial lung disease of unknown etiology. Like most forms of fibrosis, it is thought to reflect …

For over 50 years, asthma has been thought of, and treated as a disease of the smooth
muscle brought about by persistent inflammation in the airways. However, even when an …